Prion-like transmission of protein aggregates in neurodegenerative diseases.
(2010) In Nature Reviews. Molecular Cell Biology 11(4). p.301-307- Abstract
- Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1581754
- author
- Brundin, Patrik LU ; Melki, Ronald and Kopito, Ron
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews. Molecular Cell Biology
- volume
- 11
- issue
- 4
- pages
- 301 - 307
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000275850400014
- pmid:20308987
- scopus:77949848854
- pmid:20308987
- ISSN
- 1471-0072
- DOI
- 10.1038/nrm2873
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- e3d2eb2d-a4fb-4801-a0b0-93f602537897 (old id 1581754)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20308987?dopt=Abstract
- date added to LUP
- 2016-04-04 09:44:20
- date last changed
- 2022-05-09 06:23:14
@article{e3d2eb2d-a4fb-4801-a0b0-93f602537897,
abstract = {{Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.}},
author = {{Brundin, Patrik and Melki, Ronald and Kopito, Ron}},
issn = {{1471-0072}},
language = {{eng}},
number = {{4}},
pages = {{301--307}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews. Molecular Cell Biology}},
title = {{Prion-like transmission of protein aggregates in neurodegenerative diseases.}},
url = {{http://dx.doi.org/10.1038/nrm2873}},
doi = {{10.1038/nrm2873}},
volume = {{11}},
year = {{2010}},
}