Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.
Carta, Manolo LU ; Carlsson, Thomas LU ; Munoz, Ana LU ; Kirik, Deniz LU and Björklund, Anders LU
(2010)
In Movement Disorders
25 Suppl 1.
p.174-179
- Abstract
- Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such "dysregulated" release of levodopa-derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa-primed animals. This mechanism may also... (More)
- Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such "dysregulated" release of levodopa-derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa-primed animals. This mechanism may also play a role in the development of graft-induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1582813
- author
- Carta, Manolo
LU
; Carlsson, Thomas
LU
; Munoz, Ana
LU
; Kirik, Deniz
LU
and Björklund, Anders
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Movement Disorders
- volume
- 25 Suppl 1
- pages
- 174 - 179
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000276137000031
- pmid:20187238
- scopus:77953394342
- pmid:20187238
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.22792
- language
- English
- LU publication?
- yes
- id
- 7041d011-b7c8-4122-9f3f-331f47ed87fd (old id 1582813)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20187238?dopt=Abstract
- date added to LUP
- 2016-04-04 08:54:37
- date last changed
- 2022-03-15 08:56:35
@article{7041d011-b7c8-4122-9f3f-331f47ed87fd,
abstract = {{Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such "dysregulated" release of levodopa-derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa-primed animals. This mechanism may also play a role in the development of graft-induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state.}},
author = {{Carta, Manolo and Carlsson, Thomas and Munoz, Ana and Kirik, Deniz and Björklund, Anders}},
issn = {{0885-3185}},
language = {{eng}},
pages = {{174--179}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Movement Disorders}},
title = {{Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.}},
url = {{http://dx.doi.org/10.1002/mds.22792}},
doi = {{10.1002/mds.22792}},
volume = {{25 Suppl 1}},
year = {{2010}},
}