The role of low grade inflammation as measured by C-reactive protein levels in the explanation of socioeconomic differences in carotid atherosclerosis.
(2007) In European Journal of Public Health 17(4). p.340-347- Abstract
- Background: The role of inflammation as part of the explanation of socioeconomic differences in carotid atherosclerosis has not been specifically investigated. Methods and Results: The associations between socioeconomic position (SEP), C-reactive protein (CRP), and preclinical carotid atherosclerosis were investigated in a general population sample of 3921 middle-aged Swedish men and women. Common carotid intima-media thickness (IMT) and presence of carotid plaque (focal IMT > 1.2 mm) were determined by B-mode ultrasound. The results showed that low SEP was associated with increased levels of CRP, independently of established risk factors. Furthermore, common carotid IMT increased with increasing CRP-levels. Presence of carotid plaque... (More)
- Background: The role of inflammation as part of the explanation of socioeconomic differences in carotid atherosclerosis has not been specifically investigated. Methods and Results: The associations between socioeconomic position (SEP), C-reactive protein (CRP), and preclinical carotid atherosclerosis were investigated in a general population sample of 3921 middle-aged Swedish men and women. Common carotid intima-media thickness (IMT) and presence of carotid plaque (focal IMT > 1.2 mm) were determined by B-mode ultrasound. The results showed that low SEP was associated with increased levels of CRP, independently of established risk factors. Furthermore, common carotid IMT increased with increasing CRP-levels. Presence of carotid plaque increased with increasing CRP-levels in men, but not in women. While the socioeconomic differences in carotid IMT were weak, there were associations between low educational level and carotid plaque prevalence with an age- and sex-adjusted odds ratio (OR) of 1.39 (95% Cl: 1.21, 1.59). A similar association was seen for having a manual occupation, OR = 1.23 (95% Cl: 1.07, 1.42). The age- and sex-adjusted absolute differences in carotid plaque prevalence were 9% with regard to educational level and 7% with regard to occupational status. Adjustment for CRP caused only a minor attenuation of the association between SEP and carotid atherosclerosis. Conclusions: The association between SEP and carotid atherosclerosis as measured by carotid IMT and carotid plaque could only to a minor extent be referred to differences in low grade inflammation as measured by CRP. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/162093
- author
- Rosvall, Maria LU ; Engström, Gunnar LU ; Janzon, Lars LU ; Berglund, Göran LU and Hedblad, Bo LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- socioeconomic, carotid arteries, atherosclerosis, c-reactive protein, position
- in
- European Journal of Public Health
- volume
- 17
- issue
- 4
- pages
- 340 - 347
- publisher
- Oxford University Press
- external identifiers
-
- wos:000249370300006
- scopus:34547780499
- ISSN
- 1101-1262
- DOI
- 10.1093/eurpub/ckl247
- language
- English
- LU publication?
- yes
- id
- f4f9ce93-eca6-4204-bad2-d4e3961ba6b8 (old id 162093)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17068002&dopt=Abstract
- date added to LUP
- 2016-04-01 11:45:00
- date last changed
- 2022-03-05 05:52:09
@article{f4f9ce93-eca6-4204-bad2-d4e3961ba6b8,
abstract = {{Background: The role of inflammation as part of the explanation of socioeconomic differences in carotid atherosclerosis has not been specifically investigated. Methods and Results: The associations between socioeconomic position (SEP), C-reactive protein (CRP), and preclinical carotid atherosclerosis were investigated in a general population sample of 3921 middle-aged Swedish men and women. Common carotid intima-media thickness (IMT) and presence of carotid plaque (focal IMT > 1.2 mm) were determined by B-mode ultrasound. The results showed that low SEP was associated with increased levels of CRP, independently of established risk factors. Furthermore, common carotid IMT increased with increasing CRP-levels. Presence of carotid plaque increased with increasing CRP-levels in men, but not in women. While the socioeconomic differences in carotid IMT were weak, there were associations between low educational level and carotid plaque prevalence with an age- and sex-adjusted odds ratio (OR) of 1.39 (95% Cl: 1.21, 1.59). A similar association was seen for having a manual occupation, OR = 1.23 (95% Cl: 1.07, 1.42). The age- and sex-adjusted absolute differences in carotid plaque prevalence were 9% with regard to educational level and 7% with regard to occupational status. Adjustment for CRP caused only a minor attenuation of the association between SEP and carotid atherosclerosis. Conclusions: The association between SEP and carotid atherosclerosis as measured by carotid IMT and carotid plaque could only to a minor extent be referred to differences in low grade inflammation as measured by CRP.}},
author = {{Rosvall, Maria and Engström, Gunnar and Janzon, Lars and Berglund, Göran and Hedblad, Bo}},
issn = {{1101-1262}},
keywords = {{socioeconomic; carotid arteries; atherosclerosis; c-reactive protein; position}},
language = {{eng}},
number = {{4}},
pages = {{340--347}},
publisher = {{Oxford University Press}},
series = {{European Journal of Public Health}},
title = {{The role of low grade inflammation as measured by C-reactive protein levels in the explanation of socioeconomic differences in carotid atherosclerosis.}},
url = {{http://dx.doi.org/10.1093/eurpub/ckl247}},
doi = {{10.1093/eurpub/ckl247}},
volume = {{17}},
year = {{2007}},
}