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A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

Lin, Yin C. ; Jhunjhunwala, Suchit ; Benner, Christopher ; Heinz, Sven ; Welinder, Eva LU ; Mansson, Robert ; Sigvardsson, Mikael ; Hagman, James ; Espinoza, Celso A. and Dutkowski, Janusz , et al. (2010) In Nature Immunology 11(7). p.109-635
Abstract
It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions. Finally, we divided the pro-B cell epigenome into clusters of loci with occupancy by E2A, EBF and Foxo1. From this analysis we constructed a global network consisting of transcriptional... (More)
It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions. Finally, we divided the pro-B cell epigenome into clusters of loci with occupancy by E2A, EBF and Foxo1. From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Immunology
volume
11
issue
7
pages
109 - 635
publisher
Nature Publishing Group
external identifiers
  • wos:000278926400020
  • scopus:77953763449
  • pmid:20543837
ISSN
1529-2908
DOI
10.1038/ni.1891
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Connective Tissue Biology (013230151)
id
cdfc9a79-38a0-4eb6-a9c5-ac105abc6af6 (old id 1630324)
date added to LUP
2016-04-01 13:22:25
date last changed
2022-04-06 04:36:56
@article{cdfc9a79-38a0-4eb6-a9c5-ac105abc6af6,
  abstract     = {{It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in B cell development. Here we show that E2A and EBF1 bound regulatory elements present in the Foxo1 locus. E2A and EBF1, as well as E2A and Foxo1, in turn, were wired together by a vast spectrum of cis-regulatory sequences. These associations were dynamic during developmental progression. Occupancy by the E2A isoform E47 directly resulted in greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across putative enhancer regions. Finally, we divided the pro-B cell epigenome into clusters of loci with occupancy by E2A, EBF and Foxo1. From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate.}},
  author       = {{Lin, Yin C. and Jhunjhunwala, Suchit and Benner, Christopher and Heinz, Sven and Welinder, Eva and Mansson, Robert and Sigvardsson, Mikael and Hagman, James and Espinoza, Celso A. and Dutkowski, Janusz and Ideker, Trey and Glass, Christopher K. and Murre, Cornelis}},
  issn         = {{1529-2908}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{109--635}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Immunology}},
  title        = {{A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate}},
  url          = {{http://dx.doi.org/10.1038/ni.1891}},
  doi          = {{10.1038/ni.1891}},
  volume       = {{11}},
  year         = {{2010}},
}