The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes
Abdul-Ghani, Muhammad A. ; Lyssenko, Valeriya LU ; Tuomi, Tiinamaija LU
; DeFronzo, Ralph A.
and Groop, Leif
LU
(2010)
In Diabetes/Metabolism Research & Reviews
26(4).
p.280-286
- Abstract
- Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during... (More)
- Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during oGrr had greater insulin sensitivity, better beta cell function and lower risk for future T2DM. Conclusions These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM. Copyright (C) 2010 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1631416
- author
- Abdul-Ghani, Muhammad A.
; Lyssenko, Valeriya
LU
; Tuomi, Tiinamaija
LU
; DeFronzo, Ralph A.
and Groop, Leif
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- shape of glucose tolerance curve, prediction of diabetes, OGTT
- in
- Diabetes/Metabolism Research & Reviews
- volume
- 26
- issue
- 4
- pages
- 280 - 286
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000278660400007
- scopus:77952748876
- pmid:20503260
- ISSN
- 1520-7552
- DOI
- 10.1002/dmrr.1084
- language
- English
- LU publication?
- yes
- id
- ff5f9428-b66b-4a7c-a7d8-a7e6608ce782 (old id 1631416)
- date added to LUP
- 2016-04-01 10:56:08
- date last changed
- 2024-04-07 20:23:09
@article{ff5f9428-b66b-4a7c-a7d8-a7e6608ce782,
abstract = {{Background The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. Methods 2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Results NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during oGrr had greater insulin sensitivity, better beta cell function and lower risk for future T2DM. Conclusions These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM. Copyright (C) 2010 John Wiley & Sons, Ltd.}},
author = {{Abdul-Ghani, Muhammad A. and Lyssenko, Valeriya and Tuomi, Tiinamaija and DeFronzo, Ralph A. and Groop, Leif}},
issn = {{1520-7552}},
keywords = {{shape of glucose tolerance curve; prediction of diabetes; OGTT}},
language = {{eng}},
number = {{4}},
pages = {{280--286}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Diabetes/Metabolism Research & Reviews}},
title = {{The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes}},
url = {{http://dx.doi.org/10.1002/dmrr.1084}},
doi = {{10.1002/dmrr.1084}},
volume = {{26}},
year = {{2010}},
}