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Type II collagen without adjuvant induces eosinophilic arthritis.

Bockermann, Robert LU and Holmdahl, Rikard LU (2007) In European Journal of Immunology 37(2). p.540-548
Abstract
Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic... (More)
Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic disease form of destructive arthritis. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic arthritis, Eosinophils, IL-5, Th2, Th1
in
European Journal of Immunology
volume
37
issue
2
pages
540 - 548
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000244422300029
  • scopus:33947721304
ISSN
1521-4141
DOI
10.1002/eji.200636191
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
id
2e1150ea-6ede-4e41-903f-909bf33cc16d (old id 164752)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17236234&dopt=Abstract
date added to LUP
2016-04-01 12:31:03
date last changed
2022-02-26 08:11:13
@article{2e1150ea-6ede-4e41-903f-909bf33cc16d,
  abstract     = {{Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic disease form of destructive arthritis.}},
  author       = {{Bockermann, Robert and Holmdahl, Rikard}},
  issn         = {{1521-4141}},
  keywords     = {{Chronic arthritis; Eosinophils; IL-5; Th2; Th1}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{540--548}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{European Journal of Immunology}},
  title        = {{Type II collagen without adjuvant induces eosinophilic arthritis.}},
  url          = {{http://dx.doi.org/10.1002/eji.200636191}},
  doi          = {{10.1002/eji.200636191}},
  volume       = {{37}},
  year         = {{2007}},
}