Increased fetal blood pressure response to maternal norepinephrine after pharmacological inhibition f norepinephrine uptake in pregnant sheep.
Hansson, Stefan LU
; Bottalico, B
; Amer-Wåhlin, Isis
LU
; Marsal, Karel
LU
and Ley, David
LU
(2007)
In Acta Pædiatrica
96(5).
p.650-654
- Abstract
- Objective: Norepinephrine (NE) is elevated in pregnancies complicated by preeclampsia (PE). Specific uptake of NE by the NE transporter (NET) plays a central role as regulator of NE levels. Expression of NET is reduced in placentas from PE pregnancies. To study adverse fetal effects of reduced NET expression on the placental buffering capacity, the NET was pharmacologically blocked by a specific uptake inhibitor reboxetine. Study Design: We evaluated the effect of NE uptake inhibition on maternal and fetal arterial blood pressure responses to increasing maternal doses of NE in 10 chronically prepared fetal sheep. Arterial blood pressure was monitored continuously during increasing doses of iv NE. Results: NET inhibition increased both... (More)
- Objective: Norepinephrine (NE) is elevated in pregnancies complicated by preeclampsia (PE). Specific uptake of NE by the NE transporter (NET) plays a central role as regulator of NE levels. Expression of NET is reduced in placentas from PE pregnancies. To study adverse fetal effects of reduced NET expression on the placental buffering capacity, the NET was pharmacologically blocked by a specific uptake inhibitor reboxetine. Study Design: We evaluated the effect of NE uptake inhibition on maternal and fetal arterial blood pressure responses to increasing maternal doses of NE in 10 chronically prepared fetal sheep. Arterial blood pressure was monitored continuously during increasing doses of iv NE. Results: NET inhibition increased both fetal and maternal mean arterial blood pressure (p < 0.001, respectively). Conclusion: Reuptake by NET appears to be a mechanism protecting the fetus from NE. A reduced uptake capacity in preeclamptic pregnancies due to reduced NE uptake may lead to increased fetal arterial blood pressure. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/166261
- author
- Hansson, Stefan
LU
; Bottalico, B
; Amer-Wåhlin, Isis
LU
; Marsal, Karel
LU
and Ley, David
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- reboxetine, monoamine transporter, blood flow, placenta, hypertension
- in
- Acta Pædiatrica
- volume
- 96
- issue
- 5
- pages
- 650 - 654
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000245985500011
- scopus:34247520554
- pmid:17381469
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2007.00262.x
- language
- English
- LU publication?
- yes
- id
- d3836ecf-6b41-464d-a643-6bfe895be698 (old id 166261)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17381469&dopt=Abstract
- date added to LUP
- 2016-04-01 17:12:23
- date last changed
- 2022-01-29 01:06:20
@article{d3836ecf-6b41-464d-a643-6bfe895be698,
abstract = {{Objective: Norepinephrine (NE) is elevated in pregnancies complicated by preeclampsia (PE). Specific uptake of NE by the NE transporter (NET) plays a central role as regulator of NE levels. Expression of NET is reduced in placentas from PE pregnancies. To study adverse fetal effects of reduced NET expression on the placental buffering capacity, the NET was pharmacologically blocked by a specific uptake inhibitor reboxetine. Study Design: We evaluated the effect of NE uptake inhibition on maternal and fetal arterial blood pressure responses to increasing maternal doses of NE in 10 chronically prepared fetal sheep. Arterial blood pressure was monitored continuously during increasing doses of iv NE. Results: NET inhibition increased both fetal and maternal mean arterial blood pressure (p < 0.001, respectively). Conclusion: Reuptake by NET appears to be a mechanism protecting the fetus from NE. A reduced uptake capacity in preeclamptic pregnancies due to reduced NE uptake may lead to increased fetal arterial blood pressure.}},
author = {{Hansson, Stefan and Bottalico, B and Amer-Wåhlin, Isis and Marsal, Karel and Ley, David}},
issn = {{1651-2227}},
keywords = {{reboxetine; monoamine transporter; blood flow; placenta; hypertension}},
language = {{eng}},
number = {{5}},
pages = {{650--654}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Pædiatrica}},
title = {{Increased fetal blood pressure response to maternal norepinephrine after pharmacological inhibition f norepinephrine uptake in pregnant sheep.}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2007.00262.x}},
doi = {{10.1111/j.1651-2227.2007.00262.x}},
volume = {{96}},
year = {{2007}},
}