Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia
Lane, Emma L. ; Björklund, Anders LU
; Dunnett, Stephen B.
and Winkler, Christian
(2010)
In Progress in Brain Research
184.
p.295-309
- Abstract
- The development of neural transplantation as a treatment for Parkinson's disease has been compromised by a lack of functional efficacy and the appearance of transplant-induced motor side-effects in some patients. Since the first reports of these graft-induced dyskinesias (GID), and the realization of their impact on the progress of the field, a great deal of experimental work has been performed to determine the underlying cause(s) of this problematic side-effect. In this review we describe the clinical phenomenon of GID, explore the different representations of GID in rodent models, and examine the various hypotheses that have been postulated to be the cause. Based on the available clinical and preclinical data we outline strategies to... (More)
- The development of neural transplantation as a treatment for Parkinson's disease has been compromised by a lack of functional efficacy and the appearance of transplant-induced motor side-effects in some patients. Since the first reports of these graft-induced dyskinesias (GID), and the realization of their impact on the progress of the field, a great deal of experimental work has been performed to determine the underlying cause(s) of this problematic side-effect. In this review we describe the clinical phenomenon of GID, explore the different representations of GID in rodent models, and examine the various hypotheses that have been postulated to be the cause. Based on the available clinical and preclinical data we outline strategies to avoid GID in future clinical trials using fetal cell transplants or cell preparations derived from stem cells. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1859404
- author
- Lane, Emma L.
; Björklund, Anders
LU
; Dunnett, Stephen B.
and Winkler, Christian
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Parkinson's disease, Transplantation, Dopamine, Dyskinesia, Graft-induced dyskinesia, L-dopa-induced dyskinesia, Amphetamine-induced dyskinesia
- in
- Progress in Brain Research
- volume
- 184
- pages
- 295 - 309
- publisher
- Elsevier
- external identifiers
-
- wos:000287856300016
- scopus:77957235017
- pmid:20887881
- ISSN
- 1875-7855
- DOI
- 10.1016/S0079-6123(10)84015-4
- language
- English
- LU publication?
- yes
- id
- 20758363-a591-4a31-b451-e6c108b489a2 (old id 1859404)
- date added to LUP
- 2016-04-01 13:32:14
- date last changed
- 2022-03-21 19:08:22
@article{20758363-a591-4a31-b451-e6c108b489a2,
abstract = {{The development of neural transplantation as a treatment for Parkinson's disease has been compromised by a lack of functional efficacy and the appearance of transplant-induced motor side-effects in some patients. Since the first reports of these graft-induced dyskinesias (GID), and the realization of their impact on the progress of the field, a great deal of experimental work has been performed to determine the underlying cause(s) of this problematic side-effect. In this review we describe the clinical phenomenon of GID, explore the different representations of GID in rodent models, and examine the various hypotheses that have been postulated to be the cause. Based on the available clinical and preclinical data we outline strategies to avoid GID in future clinical trials using fetal cell transplants or cell preparations derived from stem cells.}},
author = {{Lane, Emma L. and Björklund, Anders and Dunnett, Stephen B. and Winkler, Christian}},
issn = {{1875-7855}},
keywords = {{Parkinson's disease; Transplantation; Dopamine; Dyskinesia; Graft-induced dyskinesia; L-dopa-induced dyskinesia; Amphetamine-induced dyskinesia}},
language = {{eng}},
pages = {{295--309}},
publisher = {{Elsevier}},
series = {{Progress in Brain Research}},
title = {{Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia}},
url = {{http://dx.doi.org/10.1016/S0079-6123(10)84015-4}},
doi = {{10.1016/S0079-6123(10)84015-4}},
volume = {{184}},
year = {{2010}},
}