Obstetric outcome after in vitro fertilization with single or double embryo transfer
(2011) In Human Reproduction 26(2). p.442-450- Abstract
- BACKGROUND: IVF children, including singletons, are known to have a poorer obstetric outcome than children born after spontaneous conception. With a broad introduction of single embryo transfer (SET), this scenario might change. This study compares the obstetric outcome after IVF with SET, elective SET (eSET), non elective SET (non-eSET) and double embryo transfer (DET) with outcomes in the general population. METHODS: All IVF children born in Sweden after IVF treatment during the years 2002-2006 (n = 13 544 children) were included and compared with all non-IVF children born during the same time period (n 587 009 children). Data were collected from all 16 Swedish IVF clinics and cross-linked with the Swedish Medical Birth Registry. Main... (More)
- BACKGROUND: IVF children, including singletons, are known to have a poorer obstetric outcome than children born after spontaneous conception. With a broad introduction of single embryo transfer (SET), this scenario might change. This study compares the obstetric outcome after IVF with SET, elective SET (eSET), non elective SET (non-eSET) and double embryo transfer (DET) with outcomes in the general population. METHODS: All IVF children born in Sweden after IVF treatment during the years 2002-2006 (n = 13 544 children) were included and compared with all non-IVF children born during the same time period (n 587 009 children). Data were collected from all 16 Swedish IVF clinics and cross-linked with the Swedish Medical Birth Registry. Main outcomes were preterm birth (< 28, < 32 and < 37 w), very-low-birthweight (VLBW) and low-birthweight (LBW). Adjusted odds ratios were calculated. RESULTS: In total, 7763 children were born after SET and 5724 children after DET. Comparing all SET children, irrespective of multiplicity, with all children in the general population, significantly higher rates of,28 w was found for the IVF children. Comparing IVF singletons, irrespective of SET and DET with non-IVF singletons from the general population, significantly higher rates of < 28 w, < 37 w, LBW and VLBW were found. eSET singletons, compared with singletons in the general population, had a significantly higher rate of < 37 w and non-eSET singletons had significantly higher rates of < 28 w and < 2500 g births. CONCLUSIONS: Children born after IVF had a poorer obstetric outcome compared with children from the general population. Singletons, when analysed as one group, irrespective of whether the children were born after eSET, non-eSET or DET, also had a poorer obstetric outcome with higher rates of preterm and LBW compared with singletons in the general population. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1869287
- author
- Sazonova, Antonina ; Källén, Karin LU ; Thurin-Kjellberg, Ann ; Wennerholm, Ulla-Britt and Bergh, Christina
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- in vitro fertilization, single embryo transfer, children outcome, maternal outcome, obstetric outcome
- in
- Human Reproduction
- volume
- 26
- issue
- 2
- pages
- 442 - 450
- publisher
- Oxford University Press
- external identifiers
-
- wos:000286470500023
- scopus:79251481466
- pmid:21126967
- ISSN
- 0268-1161
- DOI
- 10.1093/humrep/deq325
- language
- English
- LU publication?
- yes
- id
- 55840440-a0a4-4d00-98db-98fffd4b3b2c (old id 1869287)
- date added to LUP
- 2016-04-01 10:27:05
- date last changed
- 2022-03-04 19:41:50
@article{55840440-a0a4-4d00-98db-98fffd4b3b2c,
abstract = {{BACKGROUND: IVF children, including singletons, are known to have a poorer obstetric outcome than children born after spontaneous conception. With a broad introduction of single embryo transfer (SET), this scenario might change. This study compares the obstetric outcome after IVF with SET, elective SET (eSET), non elective SET (non-eSET) and double embryo transfer (DET) with outcomes in the general population. METHODS: All IVF children born in Sweden after IVF treatment during the years 2002-2006 (n = 13 544 children) were included and compared with all non-IVF children born during the same time period (n 587 009 children). Data were collected from all 16 Swedish IVF clinics and cross-linked with the Swedish Medical Birth Registry. Main outcomes were preterm birth (< 28, < 32 and < 37 w), very-low-birthweight (VLBW) and low-birthweight (LBW). Adjusted odds ratios were calculated. RESULTS: In total, 7763 children were born after SET and 5724 children after DET. Comparing all SET children, irrespective of multiplicity, with all children in the general population, significantly higher rates of,28 w was found for the IVF children. Comparing IVF singletons, irrespective of SET and DET with non-IVF singletons from the general population, significantly higher rates of < 28 w, < 37 w, LBW and VLBW were found. eSET singletons, compared with singletons in the general population, had a significantly higher rate of < 37 w and non-eSET singletons had significantly higher rates of < 28 w and < 2500 g births. CONCLUSIONS: Children born after IVF had a poorer obstetric outcome compared with children from the general population. Singletons, when analysed as one group, irrespective of whether the children were born after eSET, non-eSET or DET, also had a poorer obstetric outcome with higher rates of preterm and LBW compared with singletons in the general population.}},
author = {{Sazonova, Antonina and Källén, Karin and Thurin-Kjellberg, Ann and Wennerholm, Ulla-Britt and Bergh, Christina}},
issn = {{0268-1161}},
keywords = {{in vitro fertilization; single embryo transfer; children outcome; maternal outcome; obstetric outcome}},
language = {{eng}},
number = {{2}},
pages = {{442--450}},
publisher = {{Oxford University Press}},
series = {{Human Reproduction}},
title = {{Obstetric outcome after in vitro fertilization with single or double embryo transfer}},
url = {{http://dx.doi.org/10.1093/humrep/deq325}},
doi = {{10.1093/humrep/deq325}},
volume = {{26}},
year = {{2011}},
}