Phagosome dynamics during phagocytosis by neutrophils.
Nordenfelt, Pontus LU
and Tapper, Hans
LU
(2011)
In Journal of Leukocyte Biology
90.
p.271-284
- Abstract
- The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the formation and maturation of the phagosome, is in many respects very different from that in other phagocytes. Although the complex mechanisms that coordinate the membrane traffic, oxidative burst, and release of granule contents required for the microbicidal activities of neutrophils are not completely understood, it is evident that they are unique and differ from those in macrophages. Neutrophils exhibit more rapid rates of... (More)
- The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the formation and maturation of the phagosome, is in many respects very different from that in other phagocytes. Although the complex mechanisms that coordinate the membrane traffic, oxidative burst, and release of granule contents required for the microbicidal activities of neutrophils are not completely understood, it is evident that they are unique and differ from those in macrophages. Neutrophils exhibit more rapid rates of phagocytosis and higher intensity of oxidative respiratory response than do macrophages. The phagosome maturation pathway in macrophages, which is linked to the endocytic pathway, is replaced in neutrophils by the rapid delivery of preformed granules to nonacidic phagosomes. This review describes the plasticity and dynamics of the phagocytic process with a special focus on neutrophil phagosome maturation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1936897
- author
- Nordenfelt, Pontus
LU
and Tapper, Hans
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Leukocyte Biology
- volume
- 90
- pages
- 271 - 284
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000293338500007
- pmid:21504950
- scopus:79961057868
- pmid:21504950
- ISSN
- 1938-3673
- DOI
- 10.1189/jlb.0810457
- language
- English
- LU publication?
- yes
- id
- 6b024b65-62a8-4e5f-825c-83470f73af92 (old id 1936897)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21504950?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:14
- date last changed
- 2023-01-05 17:38:07
@article{6b024b65-62a8-4e5f-825c-83470f73af92,
abstract = {{The neutrophil is a key player in immunity, and its activities are essential for the resolution of infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial measures that leads to the highly efficient killing of pathogens. In neutrophils, the phagocytic process, including the formation and maturation of the phagosome, is in many respects very different from that in other phagocytes. Although the complex mechanisms that coordinate the membrane traffic, oxidative burst, and release of granule contents required for the microbicidal activities of neutrophils are not completely understood, it is evident that they are unique and differ from those in macrophages. Neutrophils exhibit more rapid rates of phagocytosis and higher intensity of oxidative respiratory response than do macrophages. The phagosome maturation pathway in macrophages, which is linked to the endocytic pathway, is replaced in neutrophils by the rapid delivery of preformed granules to nonacidic phagosomes. This review describes the plasticity and dynamics of the phagocytic process with a special focus on neutrophil phagosome maturation.}},
author = {{Nordenfelt, Pontus and Tapper, Hans}},
issn = {{1938-3673}},
language = {{eng}},
pages = {{271--284}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Leukocyte Biology}},
title = {{Phagosome dynamics during phagocytosis by neutrophils.}},
url = {{http://dx.doi.org/10.1189/jlb.0810457}},
doi = {{10.1189/jlb.0810457}},
volume = {{90}},
year = {{2011}},
}