SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus

Hanly, J. G.; Urowitz, M. B.; Jackson, D.; Bae, S. C.; Gordon, C.; Wallace, D. J.; Clarke, A.; Bernatsky, S.; Vasudevan, A.; Isenberg, D.; Rahman, A.; Sanchez-Guerrero, J.; Romero-Diaz, J.; Merrill, J. T.; Fortin, P. R.; Gladman, D. D.; Bruce, I. N.; Steinsson, K.; Khamashta, M.; Alarcon, G. S.; Fessler, B.; Petri, M.; Manzi, S.; Nived, Ola; Sturfelt, Gunnar; Ramsey-Goldman, R.; Dooley, M. A.; Aranow, C.; Van Vollenhoven, R.; Ramos-Casals, M.; Zoma, A.; Kalunian, K.; Farewell, V.

SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus

Mark

Hanly, J. G. ; Urowitz, M. B. ; Jackson, D. ; Bae, S. C. ; Gordon, C. ; Wallace, D. J. ; Clarke, A. ; Bernatsky, S. ; Vasudevan, A. and Isenberg, D. , et al. (2011) In Annals of the Rheumatic Diseases 70(6). p.961-967

Abstract: Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3+/-2 months.... (More); Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3+/-2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p<0.0001) following adjustments for gender, ethnicity, centre and previous score. A consistent improvement in neuropsychiatric status (N=295) was associated with an increase in the mean (SD) adjusted MCS score of 3.66 (0.89) in SF-36 scores. Between paired visits when the neuropsychiatric status consistently deteriorated (N=30), the adjusted MCS score decreased by 4.00 (1.96). For the physical component summary scores the corresponding changes were + 1.73 (0.71) and -0.62 (1.58) (p<0.05), respectively. Changes in SF-36 subscales were in the same direction (p<0.05; with the exception of role physical). Sensitivity analyses confirmed these findings. Adjustment for age, education, medications, SLE disease activity, organ damage, disease duration, attribution and characteristics of neuropsychiatric events did not substantially alter the results. Conclusion Changes in SF-36 summary and subscale scores, in particular those related to mental health, are strongly associated with the clinical outcome of neuropsychiatric events in SLE patients. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/1988045

author

Hanly, J. G. ; Urowitz, M. B. ; Jackson, D. ; Bae, S. C. ; Gordon, C. ; Wallace, D. J. ; Clarke, A. ; Bernatsky, S. ; Vasudevan, A. and Isenberg, D. , et al. (More)

Hanly, J. G. ; Urowitz, M. B. ; Jackson, D. ; Bae, S. C. ; Gordon, C. ; Wallace, D. J. ; Clarke, A. ; Bernatsky, S. ; Vasudevan, A. ; Isenberg, D. ; Rahman, A. ; Sanchez-Guerrero, J. ; Romero-Diaz, J. ; Merrill, J. T. ; Fortin, P. R. ; Gladman, D. D. ; Bruce, I. N. ; Steinsson, K. ; Khamashta, M. ; Alarcon, G. S. ; Fessler, B. ; Petri, M. ; Manzi, S. ; Nived, Ola ^LU ; Sturfelt, Gunnar ^LU ; Ramsey-Goldman, R. ; Dooley, M. A. ; Aranow, C. ; Van Vollenhoven, R. ; Ramos-Casals, M. ; Zoma, A. ; Kalunian, K. and Farewell, V. (Less)

organization

publishing date

2011

type

Contribution to journal

publication status

published

subject

Rheumatology and Autoimmunity

in

Annals of the Rheumatic Diseases

volume

70

issue

6

pages

961 - 967

publisher

BMJ Publishing Group

external identifiers

wos:000290149900014
scopus:79955863506
pmid:21342917

ISSN

1468-2060

DOI

10.1136/ard.2010.138792

language

English

LU publication?

yes

id

6c0aa646-a9c2-47f1-8afb-a3fb0fff22c3 (old id 1988045)

date added to LUP

2016-04-01 13:58:36

date last changed

2022-03-29 18:28:32

@article{6c0aa646-a9c2-47f1-8afb-a3fb0fff22c3,
  abstract     = {{Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3+/-2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p&lt;0.0001) following adjustments for gender, ethnicity, centre and previous score. A consistent improvement in neuropsychiatric status (N=295) was associated with an increase in the mean (SD) adjusted MCS score of 3.66 (0.89) in SF-36 scores. Between paired visits when the neuropsychiatric status consistently deteriorated (N=30), the adjusted MCS score decreased by 4.00 (1.96). For the physical component summary scores the corresponding changes were + 1.73 (0.71) and -0.62 (1.58) (p&lt;0.05), respectively. Changes in SF-36 subscales were in the same direction (p&lt;0.05; with the exception of role physical). Sensitivity analyses confirmed these findings. Adjustment for age, education, medications, SLE disease activity, organ damage, disease duration, attribution and characteristics of neuropsychiatric events did not substantially alter the results. Conclusion Changes in SF-36 summary and subscale scores, in particular those related to mental health, are strongly associated with the clinical outcome of neuropsychiatric events in SLE patients.}},
  author       = {{Hanly, J. G. and Urowitz, M. B. and Jackson, D. and Bae, S. C. and Gordon, C. and Wallace, D. J. and Clarke, A. and Bernatsky, S. and Vasudevan, A. and Isenberg, D. and Rahman, A. and Sanchez-Guerrero, J. and Romero-Diaz, J. and Merrill, J. T. and Fortin, P. R. and Gladman, D. D. and Bruce, I. N. and Steinsson, K. and Khamashta, M. and Alarcon, G. S. and Fessler, B. and Petri, M. and Manzi, S. and Nived, Ola and Sturfelt, Gunnar and Ramsey-Goldman, R. and Dooley, M. A. and Aranow, C. and Van Vollenhoven, R. and Ramos-Casals, M. and Zoma, A. and Kalunian, K. and Farewell, V.}},
  issn         = {{1468-2060}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{961--967}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{Annals of the Rheumatic Diseases}},
  title        = {{SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus}},
  url          = {{http://dx.doi.org/10.1136/ard.2010.138792}},
  doi          = {{10.1136/ard.2010.138792}},
  volume       = {{70}},
  year         = {{2011}},
}

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SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus