The non-haemostatic role of platelets in systemic lupus erythematosus
(2018) In Nature Reviews Rheumatology 14(4). p.195-213- Abstract
Dysregulation of lymphocyte function, accumulation of autoantibodies and defective clearance of circulating immune complexes and apoptotic cells are hallmarks of systemic lupus erythematosus (SLE). Moreover, it is now evident that an intricate interplay between the adaptive and innate immune systems contributes to the pathogenesis of SLE, ultimately resulting in chronic inflammation and organ damage. Platelets circulate in the blood and are chiefly recognized for their role in the prevention of bleeding and promotion of haemostasis; however, accumulating evidence points to a role for platelets in both adaptive and innate immunity. Through a broad repertoire of receptors, platelets respond promptly to immune complexes, complement and... (More)
Dysregulation of lymphocyte function, accumulation of autoantibodies and defective clearance of circulating immune complexes and apoptotic cells are hallmarks of systemic lupus erythematosus (SLE). Moreover, it is now evident that an intricate interplay between the adaptive and innate immune systems contributes to the pathogenesis of SLE, ultimately resulting in chronic inflammation and organ damage. Platelets circulate in the blood and are chiefly recognized for their role in the prevention of bleeding and promotion of haemostasis; however, accumulating evidence points to a role for platelets in both adaptive and innate immunity. Through a broad repertoire of receptors, platelets respond promptly to immune complexes, complement and damage-associated molecular patterns, and represent a major reservoir of immunomodulatory molecules in the circulation. Furthermore, evidence suggests that platelets are activated in patients with SLE, and that they could contribute to the circulatory autoantigenic load through the release of microparticles and mitochondrial antigens. Herein, we highlight how platelets contribute to the immune response and review evidence implicating platelets in the pathogenesis of SLE.
(Less)
- author
- Linge, Petrus LU ; Fortin, Paul R. ; Lood, Christian LU ; Bengtsson, Anders A. LU and Boilard, Eric
- organization
- publishing date
- 2018-03-21
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews Rheumatology
- volume
- 14
- issue
- 4
- pages
- 195 - 213
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85044224421
- pmid:29559714
- ISSN
- 1759-4790
- DOI
- 10.1038/nrrheum.2018.38
- language
- English
- LU publication?
- yes
- id
- 1fb2aab6-5016-4889-b245-38356dd6c199
- date added to LUP
- 2018-04-03 16:09:14
- date last changed
- 2024-04-15 04:42:20
@article{1fb2aab6-5016-4889-b245-38356dd6c199,
abstract = {{<p>Dysregulation of lymphocyte function, accumulation of autoantibodies and defective clearance of circulating immune complexes and apoptotic cells are hallmarks of systemic lupus erythematosus (SLE). Moreover, it is now evident that an intricate interplay between the adaptive and innate immune systems contributes to the pathogenesis of SLE, ultimately resulting in chronic inflammation and organ damage. Platelets circulate in the blood and are chiefly recognized for their role in the prevention of bleeding and promotion of haemostasis; however, accumulating evidence points to a role for platelets in both adaptive and innate immunity. Through a broad repertoire of receptors, platelets respond promptly to immune complexes, complement and damage-associated molecular patterns, and represent a major reservoir of immunomodulatory molecules in the circulation. Furthermore, evidence suggests that platelets are activated in patients with SLE, and that they could contribute to the circulatory autoantigenic load through the release of microparticles and mitochondrial antigens. Herein, we highlight how platelets contribute to the immune response and review evidence implicating platelets in the pathogenesis of SLE.</p>}},
author = {{Linge, Petrus and Fortin, Paul R. and Lood, Christian and Bengtsson, Anders A. and Boilard, Eric}},
issn = {{1759-4790}},
language = {{eng}},
month = {{03}},
number = {{4}},
pages = {{195--213}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews Rheumatology}},
title = {{The non-haemostatic role of platelets in systemic lupus erythematosus}},
url = {{http://dx.doi.org/10.1038/nrrheum.2018.38}},
doi = {{10.1038/nrrheum.2018.38}},
volume = {{14}},
year = {{2018}},
}