Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications
(2011) In Leukemia 25(7). p.1095-1102- Abstract
- The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of... (More)
- The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies. Leukemia (2011) 25, 1095-1102; doi:10.1038/leu.2011.52; published online 29 April 2011 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2093966
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- stem cell, iPS, gene therapy, embryonic stem cell, transplantation
- in
- Leukemia
- volume
- 25
- issue
- 7
- pages
- 1095 - 1102
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000292682600004
- scopus:79960204113
- ISSN
- 1476-5551
- DOI
- 10.1038/leu.2011.52
- language
- English
- LU publication?
- yes
- id
- b415be4e-4480-49f5-aabe-6096f350e3c8 (old id 2093966)
- date added to LUP
- 2016-04-01 13:55:24
- date last changed
- 2022-04-04 13:22:25
@article{b415be4e-4480-49f5-aabe-6096f350e3c8, abstract = {{The hematopoietic stem cell (HSC) is the prototype organ-regenerating stem cell (SC), and by far the most studied type of SC in the body. Currently, HSC-based therapy is the only routinely used SC therapy; however, advances in the field of embryonic SCs and induced pluripotent SCs may change this situation. Interest into in vitro generation of HSCs, including signals for HSC expansion and differentiation from these more primitive SCs, as well as advances in other organ-specific SCs, in particular the intestine, provide promising new applications for SC therapies. Here, we review the basic principles of different SC systems, and on the basis of the experience with HSC-based SC therapy, provide recommendations for clinical application of emerging SC technologies. Leukemia (2011) 25, 1095-1102; doi:10.1038/leu.2011.52; published online 29 April 2011}}, author = {{Staal, F. J. T. and Baum, C. and Cowan, C. and Dzierzak, E. and Hacein-Bey-Abina, S. and Karlsson, Stefan and Lapidot, T. and Lemischka, I. and Mendez-Ferrer, S. and Mikkers, H. and Moore, K. and Moreno, E. and Mummery, C. L. and Robin, C. and Suda, T. and Van Pel, M. and Brink, G. Vanden and Zwaginga, J. J. and Fibbe, W. E.}}, issn = {{1476-5551}}, keywords = {{stem cell; iPS; gene therapy; embryonic stem cell; transplantation}}, language = {{eng}}, number = {{7}}, pages = {{1095--1102}}, publisher = {{Nature Publishing Group}}, series = {{Leukemia}}, title = {{Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications}}, url = {{http://dx.doi.org/10.1038/leu.2011.52}}, doi = {{10.1038/leu.2011.52}}, volume = {{25}}, year = {{2011}}, }