Ferrochelatase: the convergence of the porphyrin biosynthesis and iron transport pathways
(2011) In Journal of Porphyrins and Phthalocyanines 15(5-6). p.350-356- Abstract
- Ferrochelatase (also known as PPIX ferrochelatase; Enzyme Commission number 4.9.9.1.1) catalyzes the insertion of ferrous iron into PPIX to form heme. This reaction unites the biochemically synchronized pathways of porphyrin synthesis and iron transport in nearly all living organisms. The ferrochelatases are an evolutionarily diverse family of enzymes with no more than six active site residues known to be perfectly conserved. The availability of over thirty different crystal structures, including many with bound metal ions or porphyrins, has added tremendously to our understanding of ferrochelatase structure and function. It is generally believed that ferrous iron is directly channeled to ferrochelatase in vivo, but the identity of the... (More)
- Ferrochelatase (also known as PPIX ferrochelatase; Enzyme Commission number 4.9.9.1.1) catalyzes the insertion of ferrous iron into PPIX to form heme. This reaction unites the biochemically synchronized pathways of porphyrin synthesis and iron transport in nearly all living organisms. The ferrochelatases are an evolutionarily diverse family of enzymes with no more than six active site residues known to be perfectly conserved. The availability of over thirty different crystal structures, including many with bound metal ions or porphyrins, has added tremendously to our understanding of ferrochelatase structure and function. It is generally believed that ferrous iron is directly channeled to ferrochelatase in vivo, but the identity of the suspected chaperone remains uncertain despite much recent progress in this area. Identification of a conserved metal ion binding site at the base of the active site cleft may be an important clue as to how ferrochelatases acquire iron, and catalyze desolvation during transport to the catalytic site to complete heme synthesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2094022
- author
- Hunter, Gregory A. ; Al-Karadaghi, Salam LU and Ferreira, Gloria C.
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ferrochelatase, iron, protoporphyrin IX, chelatase, porphyrin, tetrapyrrole, enzyme
- in
- Journal of Porphyrins and Phthalocyanines
- volume
- 15
- issue
- 5-6
- pages
- 350 - 356
- publisher
- World Scientific Publishing
- external identifiers
-
- wos:000292646900005
- scopus:79960341461
- pmid:21852895
- ISSN
- 1099-1409
- DOI
- 10.1142/S108842461100332X
- language
- English
- LU publication?
- yes
- id
- 3a3116df-1893-4e2f-a68c-9f1fdca8a66d (old id 2094022)
- date added to LUP
- 2016-04-01 10:52:01
- date last changed
- 2022-07-07 08:49:49
@article{3a3116df-1893-4e2f-a68c-9f1fdca8a66d,
abstract = {{Ferrochelatase (also known as PPIX ferrochelatase; Enzyme Commission number 4.9.9.1.1) catalyzes the insertion of ferrous iron into PPIX to form heme. This reaction unites the biochemically synchronized pathways of porphyrin synthesis and iron transport in nearly all living organisms. The ferrochelatases are an evolutionarily diverse family of enzymes with no more than six active site residues known to be perfectly conserved. The availability of over thirty different crystal structures, including many with bound metal ions or porphyrins, has added tremendously to our understanding of ferrochelatase structure and function. It is generally believed that ferrous iron is directly channeled to ferrochelatase in vivo, but the identity of the suspected chaperone remains uncertain despite much recent progress in this area. Identification of a conserved metal ion binding site at the base of the active site cleft may be an important clue as to how ferrochelatases acquire iron, and catalyze desolvation during transport to the catalytic site to complete heme synthesis.}},
author = {{Hunter, Gregory A. and Al-Karadaghi, Salam and Ferreira, Gloria C.}},
issn = {{1099-1409}},
keywords = {{ferrochelatase; iron; protoporphyrin IX; chelatase; porphyrin; tetrapyrrole; enzyme}},
language = {{eng}},
number = {{5-6}},
pages = {{350--356}},
publisher = {{World Scientific Publishing}},
series = {{Journal of Porphyrins and Phthalocyanines}},
title = {{Ferrochelatase: the convergence of the porphyrin biosynthesis and iron transport pathways}},
url = {{http://dx.doi.org/10.1142/S108842461100332X}},
doi = {{10.1142/S108842461100332X}},
volume = {{15}},
year = {{2011}},
}