Treatment of acute vestibular neuronitis with glucocorticoids.
Karlberg, Mikael LU and Magnusson, Måns LU
(2011)
In Otology & Neurotology
32(7).
p.1140-1143
- Abstract
- OBJECTIVE:
: To report the effects of glucocorticoid treatment of acute vestibular neuronitis on recovery of vestibular function and length of hospital stay.
STUDY DESIGN:
: Prospective, consecutive case series compared with historic controls.
SETTING:
: Secondary referral academic hospital.
PATIENTS:
: Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 days after symptom onset (n = 33) and 2 historic untreated control groups (n = 41 and n = 67).
INTERVENTIONS:
: Oral prednisolone 50 mg/d for 5 days with tapering of doses for the next 5 days, alternatively with intravenous... (More) - OBJECTIVE:
: To report the effects of glucocorticoid treatment of acute vestibular neuronitis on recovery of vestibular function and length of hospital stay.
STUDY DESIGN:
: Prospective, consecutive case series compared with historic controls.
SETTING:
: Secondary referral academic hospital.
PATIENTS:
: Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 days after symptom onset (n = 33) and 2 historic untreated control groups (n = 41 and n = 67).
INTERVENTIONS:
: Oral prednisolone 50 mg/d for 5 days with tapering of doses for the next 5 days, alternatively with intravenous betamethasone 8 mg on the first 1 to 2 days if nauseated.
MAIN OUTCOME MEASURES:
: Extent of unilateral vestibular paresis (%) in the caloric test at presentation and at 12 months of follow-up. Length of hospital stay (days).
RESULTS:
: The initial vestibular paresis value did not differ between the treatment group and the control group. At follow-up, the treatment group showed a lower value (22.8% versus 47.2%, p = 0.0003) and greater improvement (53.4% versus 35.6%, p = 0.002). At follow-up, 70% of the treatment group had a normal caloric test result compared to only 34% of the control group. The mean hospital stay of the treatment group was significantly shorter than that of the control group (1.8 versus 3.0 d, p = 0.001).
CONCLUSION:
: Glucocorticoids administered within 3 days after onset of vestibular neuronitis improves long-time recovery of vestibular function and reduces length of hospital stay (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2151419
- author
- Karlberg, Mikael
LU
and Magnusson, Måns
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Otology & Neurotology
- volume
- 32
- issue
- 7
- pages
- 1140 - 1143
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000293896300021
- pmid:21817947
- scopus:80052270779
- ISSN
- 1537-4505
- DOI
- 10.1097/MAO.0b013e3182267e24
- language
- English
- LU publication?
- yes
- id
- 6f252948-5064-4b71-937f-d6e32cd92c03 (old id 2151419)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21817947?dopt=Abstract
- date added to LUP
- 2016-04-04 09:07:20
- date last changed
- 2022-01-29 08:22:47
@article{6f252948-5064-4b71-937f-d6e32cd92c03,
abstract = {{OBJECTIVE:<br/><br>
: To report the effects of glucocorticoid treatment of acute vestibular neuronitis on recovery of vestibular function and length of hospital stay.<br/><br>
<br/><br>
STUDY DESIGN:<br/><br>
: Prospective, consecutive case series compared with historic controls.<br/><br>
<br/><br>
SETTING:<br/><br>
: Secondary referral academic hospital.<br/><br>
<br/><br>
PATIENTS:<br/><br>
: Patients with acute vestibular neuronitis. One group treated with glucocorticoids within 3 days after symptom onset (n = 33) and 2 historic untreated control groups (n = 41 and n = 67).<br/><br>
<br/><br>
INTERVENTIONS:<br/><br>
: Oral prednisolone 50 mg/d for 5 days with tapering of doses for the next 5 days, alternatively with intravenous betamethasone 8 mg on the first 1 to 2 days if nauseated.<br/><br>
<br/><br>
MAIN OUTCOME MEASURES:<br/><br>
: Extent of unilateral vestibular paresis (%) in the caloric test at presentation and at 12 months of follow-up. Length of hospital stay (days).<br/><br>
<br/><br>
RESULTS:<br/><br>
: The initial vestibular paresis value did not differ between the treatment group and the control group. At follow-up, the treatment group showed a lower value (22.8% versus 47.2%, p = 0.0003) and greater improvement (53.4% versus 35.6%, p = 0.002). At follow-up, 70% of the treatment group had a normal caloric test result compared to only 34% of the control group. The mean hospital stay of the treatment group was significantly shorter than that of the control group (1.8 versus 3.0 d, p = 0.001).<br/><br>
<br/><br>
CONCLUSION:<br/><br>
: Glucocorticoids administered within 3 days after onset of vestibular neuronitis improves long-time recovery of vestibular function and reduces length of hospital stay}},
author = {{Karlberg, Mikael and Magnusson, Måns}},
issn = {{1537-4505}},
language = {{eng}},
number = {{7}},
pages = {{1140--1143}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Otology & Neurotology}},
title = {{Treatment of acute vestibular neuronitis with glucocorticoids.}},
url = {{http://dx.doi.org/10.1097/MAO.0b013e3182267e24}},
doi = {{10.1097/MAO.0b013e3182267e24}},
volume = {{32}},
year = {{2011}},
}