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Composition and function of cytochrome c biogenesis System II.

Simon, Jörg and Hederstedt, Lars LU (2011) In The FEBS Journal 278(22). p.4179-4188
Abstract
Organisms employ one of several different enzyme systems to mature cytochromes c. The biosynthetic process involves the periplasmic reduction of cysteine residues in the heme c attachment motif of the apocytochrome, transmembrane transport of heme b and stereospecific covalent heme attachment via thioether bonds. The biogenesis System II (or Ccs system) is employed by β-, δ- and ε-proteobacteria, Gram-positive bacteria, Aquificales and cyanobacteria, as well as by algal and plant chloroplasts. System II comprises four (sometimes only three) membrane-bound proteins: CcsA (or ResC) and CcsB (ResB) are the components of the cytochrome c synthase, whereas CcdA and CcsX (ResA) function in the generation of a reduced heme c attachment motif.... (More)
Organisms employ one of several different enzyme systems to mature cytochromes c. The biosynthetic process involves the periplasmic reduction of cysteine residues in the heme c attachment motif of the apocytochrome, transmembrane transport of heme b and stereospecific covalent heme attachment via thioether bonds. The biogenesis System II (or Ccs system) is employed by β-, δ- and ε-proteobacteria, Gram-positive bacteria, Aquificales and cyanobacteria, as well as by algal and plant chloroplasts. System II comprises four (sometimes only three) membrane-bound proteins: CcsA (or ResC) and CcsB (ResB) are the components of the cytochrome c synthase, whereas CcdA and CcsX (ResA) function in the generation of a reduced heme c attachment motif. Some ε-proteobacteria contain CcsBA fusion proteins constituting single polypeptide cytochrome c synthases especially amenable for functional studies. This minireview highlights the recent findings on the structure, function and specificity of individual System II components and outlines the future challenges that remain to our understanding of the fascinating post-translational protein maturation process in more detail. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The FEBS Journal
volume
278
issue
22
pages
4179 - 4188
publisher
Wiley-Blackwell
external identifiers
  • wos:000297155600003
  • pmid:21955752
  • scopus:80255137210
  • pmid:21955752
ISSN
1742-464X
DOI
10.1111/j.1742-4658.2011.08374.x
language
English
LU publication?
yes
id
e6b3a9cc-9b8c-435b-ad12-dd585dc688de (old id 2201063)
date added to LUP
2016-04-01 13:01:30
date last changed
2022-02-04 01:57:05
@article{e6b3a9cc-9b8c-435b-ad12-dd585dc688de,
  abstract     = {{Organisms employ one of several different enzyme systems to mature cytochromes c. The biosynthetic process involves the periplasmic reduction of cysteine residues in the heme c attachment motif of the apocytochrome, transmembrane transport of heme b and stereospecific covalent heme attachment via thioether bonds. The biogenesis System II (or Ccs system) is employed by β-, δ- and ε-proteobacteria, Gram-positive bacteria, Aquificales and cyanobacteria, as well as by algal and plant chloroplasts. System II comprises four (sometimes only three) membrane-bound proteins: CcsA (or ResC) and CcsB (ResB) are the components of the cytochrome c synthase, whereas CcdA and CcsX (ResA) function in the generation of a reduced heme c attachment motif. Some ε-proteobacteria contain CcsBA fusion proteins constituting single polypeptide cytochrome c synthases especially amenable for functional studies. This minireview highlights the recent findings on the structure, function and specificity of individual System II components and outlines the future challenges that remain to our understanding of the fascinating post-translational protein maturation process in more detail.}},
  author       = {{Simon, Jörg and Hederstedt, Lars}},
  issn         = {{1742-464X}},
  language     = {{eng}},
  number       = {{22}},
  pages        = {{4179--4188}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{The FEBS Journal}},
  title        = {{Composition and function of cytochrome c biogenesis System II.}},
  url          = {{http://dx.doi.org/10.1111/j.1742-4658.2011.08374.x}},
  doi          = {{10.1111/j.1742-4658.2011.08374.x}},
  volume       = {{278}},
  year         = {{2011}},
}