Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study.
Chew, Michelle LU ; Linder, Adam LU ; Santén, Stefan LU ; Ersson, Anders LU ; Herwald, Heiko LU
and Thorlacius, Henrik
LU
(2012)
In Inflammation Research
61(4).
p.375-379
- Abstract
- OBJECTIVE: Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with shock. DESIGN: Fifty-three consecutive patients with septic and non-septic shock at a mixed-bed intensive care unit were included, as well as 20 age-matched controls. Patients with local infections but without signs of shock served as infectious controls. Enzyme-linked immunosorbent assay was used to determine plasma levels of HBP. RESULTS: There were no differences in serum HBP levels between healthy controls and those with local infections, including urinary tract infections, pneumonia and gastroenteritis, without shock. Levels of HBP were higher in patients with... (More)
- OBJECTIVE: Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with shock. DESIGN: Fifty-three consecutive patients with septic and non-septic shock at a mixed-bed intensive care unit were included, as well as 20 age-matched controls. Patients with local infections but without signs of shock served as infectious controls. Enzyme-linked immunosorbent assay was used to determine plasma levels of HBP. RESULTS: There were no differences in serum HBP levels between healthy controls and those with local infections, including urinary tract infections, pneumonia and gastroenteritis, without shock. Levels of HBP were higher in patients with non-septic shock and septic shock than healthy controls. However, there was no difference in serum HBP levels between patients with septic shock and those with non-septic shock. Moreover, HBP levels were not different between patients with low and high APACHE II scores. Plasma levels of HBP were similar in surviving and non-surviving patients with shock. CONCLUSIONS: HBP is elevated in patients with shock from septic and non-septic etiologies. Future investigations are required to define the functional role of HBP in patients with shock. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2273435
- author
- Chew, Michelle
LU
; Linder, Adam
LU
; Santén, Stefan
LU
; Ersson, Anders
LU
; Herwald, Heiko
LU
and Thorlacius, Henrik
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Inflammation Research
- volume
- 61
- issue
- 4
- pages
- 375 - 379
- publisher
- Birkhäuser Verlag
- external identifiers
-
- wos:000301778300012
- pmid:22207392
- scopus:84863107168
- pmid:22207392
- ISSN
- 1420-908X
- DOI
- 10.1007/s00011-011-0422-6
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery Research Unit (013242220), Emergency medicine/Medicine/Surgery (013240200), Division of Infection Medicine (BMC) (013024020), Anaesthesiology and Intensive Care (Mö) (013241110)
- id
- 95ceb12a-c75a-4750-b72e-c08aa468e52e (old id 2273435)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22207392?dopt=Abstract
- date added to LUP
- 2016-04-04 07:10:13
- date last changed
- 2022-04-23 07:51:49
@article{95ceb12a-c75a-4750-b72e-c08aa468e52e,
abstract = {{OBJECTIVE: Heparin-binding protein (HBP) is a potent inducer of increased vascular permeability. The purpose of this study was to examine plasma levels of HBP in patients with shock. DESIGN: Fifty-three consecutive patients with septic and non-septic shock at a mixed-bed intensive care unit were included, as well as 20 age-matched controls. Patients with local infections but without signs of shock served as infectious controls. Enzyme-linked immunosorbent assay was used to determine plasma levels of HBP. RESULTS: There were no differences in serum HBP levels between healthy controls and those with local infections, including urinary tract infections, pneumonia and gastroenteritis, without shock. Levels of HBP were higher in patients with non-septic shock and septic shock than healthy controls. However, there was no difference in serum HBP levels between patients with septic shock and those with non-septic shock. Moreover, HBP levels were not different between patients with low and high APACHE II scores. Plasma levels of HBP were similar in surviving and non-surviving patients with shock. CONCLUSIONS: HBP is elevated in patients with shock from septic and non-septic etiologies. Future investigations are required to define the functional role of HBP in patients with shock.}},
author = {{Chew, Michelle and Linder, Adam and Santén, Stefan and Ersson, Anders and Herwald, Heiko and Thorlacius, Henrik}},
issn = {{1420-908X}},
language = {{eng}},
number = {{4}},
pages = {{375--379}},
publisher = {{Birkhäuser Verlag}},
series = {{Inflammation Research}},
title = {{Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study.}},
url = {{http://dx.doi.org/10.1007/s00011-011-0422-6}},
doi = {{10.1007/s00011-011-0422-6}},
volume = {{61}},
year = {{2012}},
}