Epigenetic differences arise during the lifetime of monozygotic twins
(2005) In Proceedings of the National Academy of Sciences 102(30). p.10604-10609- Abstract
- Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of... (More)
- Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/229877
- author
- Fraga, MF
; Ballestar, E
; Paz, MF
; Ropero, S
; Setien, F
; Ballestart, ML
; Heine-Suner, D
; Cigudosa, JC
; Urioste, M
; Benitez, J
; Boix-Chornet, M
; Sanchez-Aguilera, A
; Ling, Charlotte
LU
; Nilsson, Emma A
LU
; Poulsen, P
; Vaag, A
; Stephan, Z
; Spector, TD
; Wu, YZ
; Plass, C
and Esteller, M
(Less) - organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- DNA methylation, epigenetics, histones
- in
- Proceedings of the National Academy of Sciences
- volume
- 102
- issue
- 30
- pages
- 10604 - 10609
- publisher
- National Academy of Sciences
- external identifiers
-
- wos:000230853300037
- scopus:23044514669
- pmid:16009939
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.0500398102
- language
- English
- LU publication?
- yes
- id
- 6d048954-aa10-4d6a-bfbc-35d8ea3e5eee (old id 229877)
- date added to LUP
- 2016-04-01 11:55:12
- date last changed
- 2024-04-08 17:41:08
@article{6d048954-aa10-4d6a-bfbc-35d8ea3e5eee,
abstract = {{Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype.}},
author = {{Fraga, MF and Ballestar, E and Paz, MF and Ropero, S and Setien, F and Ballestart, ML and Heine-Suner, D and Cigudosa, JC and Urioste, M and Benitez, J and Boix-Chornet, M and Sanchez-Aguilera, A and Ling, Charlotte and Nilsson, Emma A and Poulsen, P and Vaag, A and Stephan, Z and Spector, TD and Wu, YZ and Plass, C and Esteller, M}},
issn = {{1091-6490}},
keywords = {{DNA methylation; epigenetics; histones}},
language = {{eng}},
number = {{30}},
pages = {{10604--10609}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences}},
title = {{Epigenetic differences arise during the lifetime of monozygotic twins}},
url = {{http://dx.doi.org/10.1073/pnas.0500398102}},
doi = {{10.1073/pnas.0500398102}},
volume = {{102}},
year = {{2005}},
}