Effects of different doses of adrenocorticotrophic hormone on the serum lipoprotein profile in healthy subjects
(2005) In Basic & Clinical Pharmacology & Toxicology 97(2). p.86-90- Abstract
- Adrenocorticotrophic hormone (ACTH) at pharmacological dosage has marked lipid-lowering effects that may have therapeutic implications. The rationale behind the present investigation was the possible use of ACTH as a lipid-lowering replacement for steroids. Thirty-two healthy individuals were randomly divided into four groups of 8 each. Three ACTH groups received different doses of ACTH(1-24) intramuscularly (0.1 mg, 0.5 mg and 1.0 mg daily for four days) and the control group received NaCl 0.9% 1 ml intramuscularly daily for four days. Moreover, 8 healthy subjects were given ACTH(1-24) 1.0 mg intramuscularly five times at an interval of four days. Blood and urine samples were collected at regular intervals. ACTH treatment at the dose of... (More)
- Adrenocorticotrophic hormone (ACTH) at pharmacological dosage has marked lipid-lowering effects that may have therapeutic implications. The rationale behind the present investigation was the possible use of ACTH as a lipid-lowering replacement for steroids. Thirty-two healthy individuals were randomly divided into four groups of 8 each. Three ACTH groups received different doses of ACTH(1-24) intramuscularly (0.1 mg, 0.5 mg and 1.0 mg daily for four days) and the control group received NaCl 0.9% 1 ml intramuscularly daily for four days. Moreover, 8 healthy subjects were given ACTH(1-24) 1.0 mg intramuscularly five times at an interval of four days. Blood and urine samples were collected at regular intervals. ACTH treatment at the dose of 1.0 mg daily lowered the serum concentrations of low density lipoprotein (LDL) cholesterol and apolipoprotein B by 28% and 22%, respectively, which is similar to previous observations. ACTH treatment at the doses of 0.5 mg and 0.1 mg gave smaller reductions (17% and 12%, and 9% and 8%, respectively) resulting in near linear dose-response relationships. There were no changes in the control group. Only the ACTH dose of 1.0 mg resulted in significant changes when compared with the control group. During the ACTH administration at four-days intervals, the serum concentrations of LDL cholesterol and apolipoprotein B reached the lowest values at 48 hr after an injection, remained there at 72 hr but were rising again at 96 hr. For effective lipid reduction, an ACTH dose of about 1 mg is needed and it should be given more often than every fourth day, probably every second or third day. With regard to the cortisol exposure, the results should be viewed in the light of calculations, presented in the paper, that 1 mg of ACTH is equivalent to 90 mg of cortisol administered parenterally. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/231696
- author
- Rafnsson, AT ; Johannssonz, M ; Olafsson, I ; Dallongeville, J ; Erfurth, Eva-Marie LU ; Berg, Anna-Lena LU and Arnadottir, M
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Basic & Clinical Pharmacology & Toxicology
- volume
- 97
- issue
- 2
- pages
- 86 - 90
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000230928600004
- pmid:15998354
- scopus:22544447059
- ISSN
- 1742-7843
- DOI
- 10.1111/j.1742-7843.2005.pto_108.x
- language
- English
- LU publication?
- no
- id
- cdb0a8c6-3f2e-4151-87fd-33a9e0e3ba30 (old id 231696)
- date added to LUP
- 2016-04-01 12:25:24
- date last changed
- 2022-01-27 03:32:57
@article{cdb0a8c6-3f2e-4151-87fd-33a9e0e3ba30,
abstract = {{Adrenocorticotrophic hormone (ACTH) at pharmacological dosage has marked lipid-lowering effects that may have therapeutic implications. The rationale behind the present investigation was the possible use of ACTH as a lipid-lowering replacement for steroids. Thirty-two healthy individuals were randomly divided into four groups of 8 each. Three ACTH groups received different doses of ACTH(1-24) intramuscularly (0.1 mg, 0.5 mg and 1.0 mg daily for four days) and the control group received NaCl 0.9% 1 ml intramuscularly daily for four days. Moreover, 8 healthy subjects were given ACTH(1-24) 1.0 mg intramuscularly five times at an interval of four days. Blood and urine samples were collected at regular intervals. ACTH treatment at the dose of 1.0 mg daily lowered the serum concentrations of low density lipoprotein (LDL) cholesterol and apolipoprotein B by 28% and 22%, respectively, which is similar to previous observations. ACTH treatment at the doses of 0.5 mg and 0.1 mg gave smaller reductions (17% and 12%, and 9% and 8%, respectively) resulting in near linear dose-response relationships. There were no changes in the control group. Only the ACTH dose of 1.0 mg resulted in significant changes when compared with the control group. During the ACTH administration at four-days intervals, the serum concentrations of LDL cholesterol and apolipoprotein B reached the lowest values at 48 hr after an injection, remained there at 72 hr but were rising again at 96 hr. For effective lipid reduction, an ACTH dose of about 1 mg is needed and it should be given more often than every fourth day, probably every second or third day. With regard to the cortisol exposure, the results should be viewed in the light of calculations, presented in the paper, that 1 mg of ACTH is equivalent to 90 mg of cortisol administered parenterally.}},
author = {{Rafnsson, AT and Johannssonz, M and Olafsson, I and Dallongeville, J and Erfurth, Eva-Marie and Berg, Anna-Lena and Arnadottir, M}},
issn = {{1742-7843}},
language = {{eng}},
number = {{2}},
pages = {{86--90}},
publisher = {{Wiley-Blackwell}},
series = {{Basic & Clinical Pharmacology & Toxicology}},
title = {{Effects of different doses of adrenocorticotrophic hormone on the serum lipoprotein profile in healthy subjects}},
url = {{http://dx.doi.org/10.1111/j.1742-7843.2005.pto_108.x}},
doi = {{10.1111/j.1742-7843.2005.pto_108.x}},
volume = {{97}},
year = {{2005}},
}