Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Preparation of Calcium Alginate Nanoparticles Using Water-in-Oil (W/O) Nanoemulsions.

Machado, Alexandra LU ; Lundberg, Dan LU ; Ribeiro, António ; Veiga, Francisco ; Lindman, Björn LU ; Miguel, Maria LU and Olsson, Ulf LU (2012) In Langmuir 28(9). p.4131-4141
Abstract
A procedure for the preparation of calcium alginate nanoparticles in the aqueous phase of water-in-oil (W/O) nanoemulsions was developed. The emulsions were produced from mixtures of the nonionic surfactant tetraethylene glycol monododecyl ether (C(12)E(4)), decane, and aqueous solutions of up to 2 wt % sodium alginate by means of the phase inversion temperature (PIT) emulsification method. This method allows the preparation of finely dispersed emulsions without a large input of mechanical energy. With alginate concentrations of 1-2 wt % in the aqueous phase, emulsions showed good stability against Ostwald ripening and narrow, monomodal distributions of droplets with radii <100 nm. Gelation of the alginate was induced by the addition of... (More)
A procedure for the preparation of calcium alginate nanoparticles in the aqueous phase of water-in-oil (W/O) nanoemulsions was developed. The emulsions were produced from mixtures of the nonionic surfactant tetraethylene glycol monododecyl ether (C(12)E(4)), decane, and aqueous solutions of up to 2 wt % sodium alginate by means of the phase inversion temperature (PIT) emulsification method. This method allows the preparation of finely dispersed emulsions without a large input of mechanical energy. With alginate concentrations of 1-2 wt % in the aqueous phase, emulsions showed good stability against Ostwald ripening and narrow, monomodal distributions of droplets with radii <100 nm. Gelation of the alginate was induced by the addition of aqueous CaCl(2) to the emulsions under stirring, and particles formed were collected using a simple procedure based on extraction of the surfactant on addition of excess oil. The final particles were characterized using cryo-transmission electron microscopy (cryo-TEM) and dynamic light scattering (DLS). They were found to be essentially spherical with a homogeneous interior, and their size was similar to that of the initial emulsion droplets. The herein presented "low-energy" method for preparation of biocompatible nanoparticles has the potential to be used in various applications, e.g., for the encapsulation of sensitive biomacromolecules. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
28
issue
9
pages
4131 - 4141
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000301038000013
  • pmid:22296569
  • scopus:84857848619
  • pmid:22296569
ISSN
0743-7463
DOI
10.1021/la204944j
language
English
LU publication?
yes
id
a847d384-38b8-40f3-b3c9-9278cf69636e (old id 2367473)
date added to LUP
2016-04-01 09:55:45
date last changed
2022-04-27 08:41:04
@article{a847d384-38b8-40f3-b3c9-9278cf69636e,
  abstract     = {{A procedure for the preparation of calcium alginate nanoparticles in the aqueous phase of water-in-oil (W/O) nanoemulsions was developed. The emulsions were produced from mixtures of the nonionic surfactant tetraethylene glycol monododecyl ether (C(12)E(4)), decane, and aqueous solutions of up to 2 wt % sodium alginate by means of the phase inversion temperature (PIT) emulsification method. This method allows the preparation of finely dispersed emulsions without a large input of mechanical energy. With alginate concentrations of 1-2 wt % in the aqueous phase, emulsions showed good stability against Ostwald ripening and narrow, monomodal distributions of droplets with radii &lt;100 nm. Gelation of the alginate was induced by the addition of aqueous CaCl(2) to the emulsions under stirring, and particles formed were collected using a simple procedure based on extraction of the surfactant on addition of excess oil. The final particles were characterized using cryo-transmission electron microscopy (cryo-TEM) and dynamic light scattering (DLS). They were found to be essentially spherical with a homogeneous interior, and their size was similar to that of the initial emulsion droplets. The herein presented "low-energy" method for preparation of biocompatible nanoparticles has the potential to be used in various applications, e.g., for the encapsulation of sensitive biomacromolecules.}},
  author       = {{Machado, Alexandra and Lundberg, Dan and Ribeiro, António and Veiga, Francisco and Lindman, Björn and Miguel, Maria and Olsson, Ulf}},
  issn         = {{0743-7463}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{4131--4141}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Langmuir}},
  title        = {{Preparation of Calcium Alginate Nanoparticles Using Water-in-Oil (W/O) Nanoemulsions.}},
  url          = {{http://dx.doi.org/10.1021/la204944j}},
  doi          = {{10.1021/la204944j}},
  volume       = {{28}},
  year         = {{2012}},
}