Fast metabolite mapping in the pig heart after injection of hyperpolarized (13) C-pyruvate with low-flip angle balanced steady-state free precession imaging.
Månsson, Sven LU
; Petersson, J Stefan
and Scheffler, Klaus
(2012)
In Magnetic Resonance in Medicine
68(6).
p.1894-1899
- Abstract
- The conversion of hyperpolarized (13) C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different (13) C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized (13) C(1) -pyruvate. Using cardiac gating, it was possible to acquire (13) C-bicarbonate images within a single heartbeat (acquisition time 150... (More)
- The conversion of hyperpolarized (13) C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different (13) C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized (13) C(1) -pyruvate. Using cardiac gating, it was possible to acquire (13) C-bicarbonate images within a single heartbeat (acquisition time 150 ms) without destroying the substrate signal from the hyperpolarized pyruvate. Therefore, the technique may be useful in dynamic studies of cardiac metabolism. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2367491
- author
- Månsson, Sven
LU
; Petersson, J Stefan
and Scheffler, Klaus
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 13C pyruvate, hyperpolarized 13C, balanced SSFP, spectral selectivity, metabolite mapping
- in
- Magnetic Resonance in Medicine
- volume
- 68
- issue
- 6
- pages
- 1894 - 1899
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000311398600023
- pmid:22294528
- scopus:84870052802
- pmid:22294528
- ISSN
- 1522-2594
- DOI
- 10.1002/mrm.24183
- language
- English
- LU publication?
- yes
- id
- e79c6db7-7c50-4189-b09e-90462eff299f (old id 2367491)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22294528?dopt=Abstract
- date added to LUP
- 2016-04-01 10:27:01
- date last changed
- 2022-05-17 23:04:51
@article{e79c6db7-7c50-4189-b09e-90462eff299f,
abstract = {{The conversion of hyperpolarized (13) C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different (13) C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized (13) C(1) -pyruvate. Using cardiac gating, it was possible to acquire (13) C-bicarbonate images within a single heartbeat (acquisition time 150 ms) without destroying the substrate signal from the hyperpolarized pyruvate. Therefore, the technique may be useful in dynamic studies of cardiac metabolism. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.}},
author = {{Månsson, Sven and Petersson, J Stefan and Scheffler, Klaus}},
issn = {{1522-2594}},
keywords = {{13C pyruvate; hyperpolarized 13C; balanced SSFP; spectral selectivity; metabolite mapping}},
language = {{eng}},
number = {{6}},
pages = {{1894--1899}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Magnetic Resonance in Medicine}},
title = {{Fast metabolite mapping in the pig heart after injection of hyperpolarized (13) C-pyruvate with low-flip angle balanced steady-state free precession imaging.}},
url = {{http://dx.doi.org/10.1002/mrm.24183}},
doi = {{10.1002/mrm.24183}},
volume = {{68}},
year = {{2012}},
}