A multivariate genetic analysis of specific phobia, separation anxiety and social phobia in early childhood
Eley, Thalia ; Rijsdijk, Fruhling ; Perrin, Sean LU
; O'Connor, Thomas
and Bolton, Derek
(2008)
In Journal of Abnormal Child Psychology
36(6).
p.839-848
- Abstract
- Background: Comorbidity amongst anxiety disorders is
very common in children as in adults and leads to
considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We examined the genetic and environmental influences on
the comorbidity between three common childhood anxiety disorders: Specific Phobia, Separation Anxiety and Social Phobia. Methods Using a two-phase design 4,662 twin-pairs were screened in the first phase and 854 pairs were assessed in
the second phase by maternal-informant diagnostic interview using DSM-IV criteria.... (More) - Background: Comorbidity amongst anxiety disorders is
very common in children as in adults and leads to
considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We examined the genetic and environmental influences on
the comorbidity between three common childhood anxiety disorders: Specific Phobia, Separation Anxiety and Social Phobia. Methods Using a two-phase design 4,662 twin-pairs were screened in the first phase and 854 pairs were assessed in
the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results: Multivariate genetic analysis revealed significant
shared environmental over-lap between Specific Phobia and Separation Anxiety and significant familial and non-shared environmental over-lap between Specific Phobia and Social Phobia.
Conclusions: Familial influences, especially shared environment, are central to the comorbidity between Specific Phobia and both Separation Anxiety and Social Phobia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2373319
- author
- Eley, Thalia
; Rijsdijk, Fruhling
; Perrin, Sean
LU
; O'Connor, Thomas
and Bolton, Derek
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Twins, Genetics, Environment, Anxiety Disorders, Children
- in
- Journal of Abnormal Child Psychology
- volume
- 36
- issue
- 6
- pages
- 839 - 848
- publisher
- Springer
- external identifiers
-
- scopus:47549113324
- pmid:18270811
- ISSN
- 0091-0627
- DOI
- 10.1007/s10802-008-9216-x
- language
- English
- LU publication?
- no
- id
- ad0ad714-ac81-4d10-af01-10f8a076fbaf (old id 2373319)
- date added to LUP
- 2016-04-04 10:16:17
- date last changed
- 2022-01-29 20:04:26
@article{ad0ad714-ac81-4d10-af01-10f8a076fbaf,
abstract = {{Background: Comorbidity amongst anxiety disorders is<br/><br>
very common in children as in adults and leads to<br/><br>
considerable distress and impairment, yet is poorly understood. Multivariate genetic analyses can shed light on the origins of this comorbidity by revealing whether genetic or environmental risks for one disorder also influence another. We examined the genetic and environmental influences on<br/><br>
the comorbidity between three common childhood anxiety disorders: Specific Phobia, Separation Anxiety and Social Phobia. Methods Using a two-phase design 4,662 twin-pairs were screened in the first phase and 854 pairs were assessed in<br/><br>
the second phase by maternal-informant diagnostic interview using DSM-IV criteria. Results: Multivariate genetic analysis revealed significant<br/><br>
shared environmental over-lap between Specific Phobia and Separation Anxiety and significant familial and non-shared environmental over-lap between Specific Phobia and Social Phobia.<br/><br>
Conclusions: Familial influences, especially shared environment, are central to the comorbidity between Specific Phobia and both Separation Anxiety and Social Phobia.}},
author = {{Eley, Thalia and Rijsdijk, Fruhling and Perrin, Sean and O'Connor, Thomas and Bolton, Derek}},
issn = {{0091-0627}},
keywords = {{Twins; Genetics; Environment; Anxiety Disorders; Children}},
language = {{eng}},
number = {{6}},
pages = {{839--848}},
publisher = {{Springer}},
series = {{Journal of Abnormal Child Psychology}},
title = {{A multivariate genetic analysis of specific phobia, separation anxiety and social phobia in early childhood}},
url = {{http://dx.doi.org/10.1007/s10802-008-9216-x}},
doi = {{10.1007/s10802-008-9216-x}},
volume = {{36}},
year = {{2008}},
}