Textile Dyes Disperse Orange 1 and Yellow 3 Contain More Than One Allergen As Shown by Patch Testing with Thin-Layer Chromatograms
(2011) In Dermatitis 22(6). p.335-343- Abstract
- Background:
It is known that some patch-test preparations containing disperse dyes contain impurities with unknown relevance for the development or elicitation of contact allergy.
Objective:
To evaluate the significance of the impurities found in the commercial dyes Disperse Orange 1 (DO1) and Disperse Yellow 3 (DY3) regarding contact allergy in patients with known sensitivity to them.
Methods:
Ten patients allergic to DY3 and/or DO1 were tested with a dilution series of commercial and purified DY3 and DO1 (with water-soluble parts prepared from the commercial dyes) and with naphthalene sulfonate. Nine patients were additionally tested with thin-layer chromatograms... (More) - Background:
It is known that some patch-test preparations containing disperse dyes contain impurities with unknown relevance for the development or elicitation of contact allergy.
Objective:
To evaluate the significance of the impurities found in the commercial dyes Disperse Orange 1 (DO1) and Disperse Yellow 3 (DY3) regarding contact allergy in patients with known sensitivity to them.
Methods:
Ten patients allergic to DY3 and/or DO1 were tested with a dilution series of commercial and purified DY3 and DO1 (with water-soluble parts prepared from the commercial dyes) and with naphthalene sulfonate. Nine patients were additionally tested with thin-layer chromatograms (TLCs) made from the commercial DO1 and DY3 and with paper chromatograms made from the water-soluble part of these dyes.
Results:
Eight of nine and three of six patients tested positively to the TLCs of DO1 and DY3, respectively. Among them, 4 of 8 and 2 of 3 patients, respectively, were positive also to another spot on the TLCs. One patient was positive to the paper chromatogram from the water-soluble part of DO1. None of the tested patients reacted to naphthalene sulfonate.
Conclusion:
The results of our study suggest that there are more relevant allergens in the fat-soluble and water-soluble fractions of the commercial disperse dyes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2378586
- author
- Malinauskiene, Laura LU ; Zimerson, Erik LU ; Bruze, Magnus LU ; Ryberg, Kristina LU and Isaksson, Marléne LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Dermatitis
- volume
- 22
- issue
- 6
- pages
- 335 - 343
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000299973300005
- scopus:82455191748
- ISSN
- 1710-3568
- DOI
- 10.2310/6620.2011.11043
- language
- English
- LU publication?
- yes
- id
- 3348d925-cf0a-49bf-898b-e4d5dfb8c82b (old id 2378586)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22653007?dopt=Abstract
- date added to LUP
- 2016-04-01 10:01:53
- date last changed
- 2022-01-25 19:06:12
@article{3348d925-cf0a-49bf-898b-e4d5dfb8c82b,
abstract = {{Background: <br/><br>
It is known that some patch-test preparations containing disperse dyes contain impurities with unknown relevance for the development or elicitation of contact allergy. <br/><br>
<br/><br>
Objective: <br/><br>
To evaluate the significance of the impurities found in the commercial dyes Disperse Orange 1 (DO1) and Disperse Yellow 3 (DY3) regarding contact allergy in patients with known sensitivity to them. <br/><br>
<br/><br>
Methods: <br/><br>
Ten patients allergic to DY3 and/or DO1 were tested with a dilution series of commercial and purified DY3 and DO1 (with water-soluble parts prepared from the commercial dyes) and with naphthalene sulfonate. Nine patients were additionally tested with thin-layer chromatograms (TLCs) made from the commercial DO1 and DY3 and with paper chromatograms made from the water-soluble part of these dyes. <br/><br>
<br/><br>
Results: <br/><br>
Eight of nine and three of six patients tested positively to the TLCs of DO1 and DY3, respectively. Among them, 4 of 8 and 2 of 3 patients, respectively, were positive also to another spot on the TLCs. One patient was positive to the paper chromatogram from the water-soluble part of DO1. None of the tested patients reacted to naphthalene sulfonate. <br/><br>
<br/><br>
Conclusion: <br/><br>
The results of our study suggest that there are more relevant allergens in the fat-soluble and water-soluble fractions of the commercial disperse dyes.}},
author = {{Malinauskiene, Laura and Zimerson, Erik and Bruze, Magnus and Ryberg, Kristina and Isaksson, Marléne}},
issn = {{1710-3568}},
language = {{eng}},
number = {{6}},
pages = {{335--343}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Dermatitis}},
title = {{Textile Dyes Disperse Orange 1 and Yellow 3 Contain More Than One Allergen As Shown by Patch Testing with Thin-Layer Chromatograms}},
url = {{http://dx.doi.org/10.2310/6620.2011.11043}},
doi = {{10.2310/6620.2011.11043}},
volume = {{22}},
year = {{2011}},
}