DPP-4 inhibition and islet function
(2012) In Journal of Diabetes Investigation 3(1). p.3-10- Abstract
- During recent years, dipeptidyl peptidase-4 (DPP-4) inhibition has been included in the clinical management of type 2 diabetes, both as monotherapy and as add-on to several other therapies. DPP-4 inhibition prevents the inactivation of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). This results in stimulation of insulin secretion and inhibition of glucagon secretion, and there is also a potential beta-cell preservation effect, as judged from rodent studies; that is, it might target the key islet dysfunction in the disease. In type 2 diabetes. This reduces 24-h glucose levels and reduces HbA1c by approximate to 0.81.1% from baseline levels of 7.78.5%. DPP-4 inhibition is safe,... (More)
- During recent years, dipeptidyl peptidase-4 (DPP-4) inhibition has been included in the clinical management of type 2 diabetes, both as monotherapy and as add-on to several other therapies. DPP-4 inhibition prevents the inactivation of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). This results in stimulation of insulin secretion and inhibition of glucagon secretion, and there is also a potential beta-cell preservation effect, as judged from rodent studies; that is, it might target the key islet dysfunction in the disease. In type 2 diabetes. This reduces 24-h glucose levels and reduces HbA1c by approximate to 0.81.1% from baseline levels of 7.78.5%. DPP-4 inhibition is safe, with a very low risk for adverse events including hypoglycemia, and it prevents weight gain. The present review summarizes the studies on the influence of DPP-4 inhibition on islet function. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00184.x, 2012) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2403206
- author
- Ahrén, Bo LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dipeptidyl peptidase-4 inhibition, Glucagon secretion, Insulin secretion
- in
- Journal of Diabetes Investigation
- volume
- 3
- issue
- 1
- pages
- 3 - 10
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000300678900002
- scopus:84857226676
- ISSN
- 2040-1116
- DOI
- 10.1111/j.2040-1124.2011.00184.x
- language
- English
- LU publication?
- yes
- id
- 2a2910d5-19d6-4bd4-a427-d88f7a1c053e (old id 2403206)
- date added to LUP
- 2016-04-01 10:44:19
- date last changed
- 2024-01-07 00:05:07
@article{2a2910d5-19d6-4bd4-a427-d88f7a1c053e,
abstract = {{During recent years, dipeptidyl peptidase-4 (DPP-4) inhibition has been included in the clinical management of type 2 diabetes, both as monotherapy and as add-on to several other therapies. DPP-4 inhibition prevents the inactivation of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). This results in stimulation of insulin secretion and inhibition of glucagon secretion, and there is also a potential beta-cell preservation effect, as judged from rodent studies; that is, it might target the key islet dysfunction in the disease. In type 2 diabetes. This reduces 24-h glucose levels and reduces HbA1c by approximate to 0.81.1% from baseline levels of 7.78.5%. DPP-4 inhibition is safe, with a very low risk for adverse events including hypoglycemia, and it prevents weight gain. The present review summarizes the studies on the influence of DPP-4 inhibition on islet function. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00184.x, 2012)}},
author = {{Ahrén, Bo}},
issn = {{2040-1116}},
keywords = {{Dipeptidyl peptidase-4 inhibition; Glucagon secretion; Insulin secretion}},
language = {{eng}},
number = {{1}},
pages = {{3--10}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Diabetes Investigation}},
title = {{DPP-4 inhibition and islet function}},
url = {{http://dx.doi.org/10.1111/j.2040-1124.2011.00184.x}},
doi = {{10.1111/j.2040-1124.2011.00184.x}},
volume = {{3}},
year = {{2012}},
}