Relation between reduction of foveal thickness and visual acuity in diabetic macular edema treated with intravitreal triamcinolone
(2005) In American Journal of Ophthalmology 139(5). p.802-806- Abstract
- PURPOSE: To evaluate the correlation between improvement in visual acuity and the reduction of foveal thickness after a single intravitreal injection of 4 mg of triamcinolone in diabetic macular edema. DESIGN: Prospective, interventional, nonrandomized clinical trial. METHOD: PATIENTS: In a prospective study 24 eyes with diabetic macular edema were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. MAIN OUTCOME MEASURES: Best,corrected logMAR visual acuity and optical coherence tomography were performed at baseline and 3 months after the treatment. RESULTS: At baseline the average foveal thickness was 462 ± 154 μ m (95% confidence interval, 397-527 μ m) and at 3 months 257 ± 114 μ m (95%... (More)
- PURPOSE: To evaluate the correlation between improvement in visual acuity and the reduction of foveal thickness after a single intravitreal injection of 4 mg of triamcinolone in diabetic macular edema. DESIGN: Prospective, interventional, nonrandomized clinical trial. METHOD: PATIENTS: In a prospective study 24 eyes with diabetic macular edema were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. MAIN OUTCOME MEASURES: Best,corrected logMAR visual acuity and optical coherence tomography were performed at baseline and 3 months after the treatment. RESULTS: At baseline the average foveal thickness was 462 &PLUSMN; 154 μ m (95% confidence interval, 397-527 μ m) and at 3 months 257 &PLUSMN; 114 μ m (95% confidence interval, 209-305 μ m) (P < .0001). The best-corrected logMAR average visual acuity was 60.5 &PLUSMN; 10.5 (95% confidence interval, 56.0-65.0) ETDRS letters at base, line compared with 65.5 &PLUSMN; 11.1 (95% confidence interval, 60.8-70.1) 3 months after the injection (P = .0001). There was no correlation between the improvement in visual acuity and the reduction of foveal thickness (r = 0.054, P = .8), but there was a correlation between reduction in foveal thickness and the age of the patients (r = 0.53, P = .008). CONCLUSION: A single injection of 4 mg of intravitreal triamcinolone acetonide effectively reduces the foveal thickness in diabetic macular edema and improves visual acuity, but there does not appear to be a strong correlation between the reduction of foveal thickness and the improvement in visual acuity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/240668
- author
- Larsson, Jörgen LU ; Zhu, MD ; Sutter, F and Gillies, MC
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Ophthalmology
- volume
- 139
- issue
- 5
- pages
- 802 - 806
- publisher
- Elsevier
- external identifiers
-
- pmid:15860283
- wos:000228950500005
- scopus:18144381156
- ISSN
- 1879-1891
- DOI
- 10.1016/j.ajo.2004.12.054
- language
- English
- LU publication?
- yes
- id
- 348a70a5-4cb4-44b2-909b-2c7780ec0776 (old id 240668)
- date added to LUP
- 2016-04-01 17:06:34
- date last changed
- 2022-01-29 00:23:04
@article{348a70a5-4cb4-44b2-909b-2c7780ec0776,
abstract = {{PURPOSE: To evaluate the correlation between improvement in visual acuity and the reduction of foveal thickness after a single intravitreal injection of 4 mg of triamcinolone in diabetic macular edema. DESIGN: Prospective, interventional, nonrandomized clinical trial. METHOD: PATIENTS: In a prospective study 24 eyes with diabetic macular edema were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. MAIN OUTCOME MEASURES: Best,corrected logMAR visual acuity and optical coherence tomography were performed at baseline and 3 months after the treatment. RESULTS: At baseline the average foveal thickness was 462 &PLUSMN; 154 μ m (95% confidence interval, 397-527 μ m) and at 3 months 257 &PLUSMN; 114 μ m (95% confidence interval, 209-305 μ m) (P < .0001). The best-corrected logMAR average visual acuity was 60.5 &PLUSMN; 10.5 (95% confidence interval, 56.0-65.0) ETDRS letters at base, line compared with 65.5 &PLUSMN; 11.1 (95% confidence interval, 60.8-70.1) 3 months after the injection (P = .0001). There was no correlation between the improvement in visual acuity and the reduction of foveal thickness (r = 0.054, P = .8), but there was a correlation between reduction in foveal thickness and the age of the patients (r = 0.53, P = .008). CONCLUSION: A single injection of 4 mg of intravitreal triamcinolone acetonide effectively reduces the foveal thickness in diabetic macular edema and improves visual acuity, but there does not appear to be a strong correlation between the reduction of foveal thickness and the improvement in visual acuity.}},
author = {{Larsson, Jörgen and Zhu, MD and Sutter, F and Gillies, MC}},
issn = {{1879-1891}},
language = {{eng}},
number = {{5}},
pages = {{802--806}},
publisher = {{Elsevier}},
series = {{American Journal of Ophthalmology}},
title = {{Relation between reduction of foveal thickness and visual acuity in diabetic macular edema treated with intravitreal triamcinolone}},
url = {{http://dx.doi.org/10.1016/j.ajo.2004.12.054}},
doi = {{10.1016/j.ajo.2004.12.054}},
volume = {{139}},
year = {{2005}},
}