Early life low-level cadmium exposure is positively associated with increased oxidative stress
Kippler, Maria ; Hossain, Mohammad Bakhtiar ; Lindh, Christian LU
; Moore, Sophie E.
; Kabir, Iqbal
; Vahter, Marie
and Broberg Palmgren, Karin
LU
(2012)
In Environmental Research
112.
p.164-170
- Abstract
- Environmental exposure to cadmium (Cd) is known to induce oxidative stress, a state of imbalance between the production of reactive oxygen species (ROS) and the ability to detoxify them, in adults. However, data are lacking on potential effects in early-life. We evaluated urinary concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a recognized marker of oxidative DNA damage, in relation to Cd exposure in 96 predominantly breast-fed infants (11-17 weeks of age) in rural Bangladesh. Urinary 8-oxodG was measured using liquid chromatography tandem mass spectrometry and Cd in urine and breast milk by inductively coupled plasma mass spectrometry. Median concentration of 8-oxodG was 3.9 nmol/L, urinary Cd 0.30 mu g/L, and breast-milk... (More)
- Environmental exposure to cadmium (Cd) is known to induce oxidative stress, a state of imbalance between the production of reactive oxygen species (ROS) and the ability to detoxify them, in adults. However, data are lacking on potential effects in early-life. We evaluated urinary concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a recognized marker of oxidative DNA damage, in relation to Cd exposure in 96 predominantly breast-fed infants (11-17 weeks of age) in rural Bangladesh. Urinary 8-oxodG was measured using liquid chromatography tandem mass spectrometry and Cd in urine and breast milk by inductively coupled plasma mass spectrometry. Median concentration of 8-oxodG was 3.9 nmol/L, urinary Cd 0.30 mu g/L, and breast-milk Cd 0.13 mu g/L. In linear regression analyses, urinary 8-oxodG was positively associated with Cd in both urine (p=0.00067) and breast milk (p=0.0021), and negatively associated with body weight (kg: p=0.0041). Adjustment for age, body weight, socio-economic status, urinary arsenic, as well as magnesium, calcium, and copper in breast milk did not change the association between Cd exposure and urinary 8-oxodG. These findings suggest that early-life low-level exposure to Cd via breast milk induces oxidative stress. Further studies are warranted to elucidate whether this oxidative stress is associated with impaired child health and development. (C) 2011 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2409705
- author
- Kippler, Maria
; Hossain, Mohammad Bakhtiar
; Lindh, Christian
LU
; Moore, Sophie E.
; Kabir, Iqbal
; Vahter, Marie
and Broberg Palmgren, Karin
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 8-oxodG, DNA damage, Infant, Cadmium, Breast-feeding
- in
- Environmental Research
- volume
- 112
- pages
- 164 - 170
- publisher
- Elsevier
- external identifiers
-
- wos:000299804800021
- scopus:84856211031
- pmid:22192840
- ISSN
- 1096-0953
- DOI
- 10.1016/j.envres.2011.11.012
- language
- English
- LU publication?
- yes
- id
- 3ab95f1c-c8fe-49dc-8c56-36bd824bca18 (old id 2409705)
- date added to LUP
- 2016-04-01 10:27:38
- date last changed
- 2022-04-27 22:19:39
@article{3ab95f1c-c8fe-49dc-8c56-36bd824bca18,
abstract = {{Environmental exposure to cadmium (Cd) is known to induce oxidative stress, a state of imbalance between the production of reactive oxygen species (ROS) and the ability to detoxify them, in adults. However, data are lacking on potential effects in early-life. We evaluated urinary concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a recognized marker of oxidative DNA damage, in relation to Cd exposure in 96 predominantly breast-fed infants (11-17 weeks of age) in rural Bangladesh. Urinary 8-oxodG was measured using liquid chromatography tandem mass spectrometry and Cd in urine and breast milk by inductively coupled plasma mass spectrometry. Median concentration of 8-oxodG was 3.9 nmol/L, urinary Cd 0.30 mu g/L, and breast-milk Cd 0.13 mu g/L. In linear regression analyses, urinary 8-oxodG was positively associated with Cd in both urine (p=0.00067) and breast milk (p=0.0021), and negatively associated with body weight (kg: p=0.0041). Adjustment for age, body weight, socio-economic status, urinary arsenic, as well as magnesium, calcium, and copper in breast milk did not change the association between Cd exposure and urinary 8-oxodG. These findings suggest that early-life low-level exposure to Cd via breast milk induces oxidative stress. Further studies are warranted to elucidate whether this oxidative stress is associated with impaired child health and development. (C) 2011 Elsevier Inc. All rights reserved.}},
author = {{Kippler, Maria and Hossain, Mohammad Bakhtiar and Lindh, Christian and Moore, Sophie E. and Kabir, Iqbal and Vahter, Marie and Broberg Palmgren, Karin}},
issn = {{1096-0953}},
keywords = {{8-oxodG; DNA damage; Infant; Cadmium; Breast-feeding}},
language = {{eng}},
pages = {{164--170}},
publisher = {{Elsevier}},
series = {{Environmental Research}},
title = {{Early life low-level cadmium exposure is positively associated with increased oxidative stress}},
url = {{http://dx.doi.org/10.1016/j.envres.2011.11.012}},
doi = {{10.1016/j.envres.2011.11.012}},
volume = {{112}},
year = {{2012}},
}