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Formation of Bone-like Nanocrystalline Apatite Using Self-Assembled Liquid Crystals

He, Wenxiao ; Kjellin, Per ; Currie, Fredrik ; Handa, Paul ; Knee, Christopher S. ; Bielecki, Johan ; Wallenberg, Reine LU and Andersson, Martin (2012) In Chemistry of Materials 24(5). p.892-902
Abstract
A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were... (More)
A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were characterized by X-ray diffraction, conventional and high-resolution transmission electron microscopy, nitrogen adsorption, thermogravimetry with infrared-coupled analysis, and Raman spectroscopy. The PCA formed using the LC aging route presented bone-resembling features, such as,Ca2+ and OH- deficiency, CO32- substitution, poor crystallinity; and ultrahigh SSA of 356 m(2)/g. The resulting particles were compared to hydroxyapatite synthesized via a conventional water-based precipitation method. The LC-aging route exhibited excellent controllability over the CaP crystallization, which enabled facile tailoring of the resulting material properties for different types of application. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
liquid crystalline phase, nanoparticles, calcium, phosphate, apatite, bone
in
Chemistry of Materials
volume
24
issue
5
pages
892 - 902
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000301398100015
  • scopus:84858233138
ISSN
0897-4756
DOI
10.1021/cm201077t
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Polymer and Materials Chemistry (LTH) (011001041)
id
873ec1ca-f7c6-4c75-8b21-1a6f3f571d2d (old id 2515532)
date added to LUP
2016-04-01 10:22:20
date last changed
2023-11-09 19:16:03
@article{873ec1ca-f7c6-4c75-8b21-1a6f3f571d2d,
  abstract     = {{A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were characterized by X-ray diffraction, conventional and high-resolution transmission electron microscopy, nitrogen adsorption, thermogravimetry with infrared-coupled analysis, and Raman spectroscopy. The PCA formed using the LC aging route presented bone-resembling features, such as,Ca2+ and OH- deficiency, CO32- substitution, poor crystallinity; and ultrahigh SSA of 356 m(2)/g. The resulting particles were compared to hydroxyapatite synthesized via a conventional water-based precipitation method. The LC-aging route exhibited excellent controllability over the CaP crystallization, which enabled facile tailoring of the resulting material properties for different types of application.}},
  author       = {{He, Wenxiao and Kjellin, Per and Currie, Fredrik and Handa, Paul and Knee, Christopher S. and Bielecki, Johan and Wallenberg, Reine and Andersson, Martin}},
  issn         = {{0897-4756}},
  keywords     = {{liquid crystalline phase; nanoparticles; calcium; phosphate; apatite; bone}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{892--902}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Chemistry of Materials}},
  title        = {{Formation of Bone-like Nanocrystalline Apatite Using Self-Assembled Liquid Crystals}},
  url          = {{http://dx.doi.org/10.1021/cm201077t}},
  doi          = {{10.1021/cm201077t}},
  volume       = {{24}},
  year         = {{2012}},
}