Beyond α-synuclein transfer: pathology propagation in Parkinson's disease.
(2012) In Trends in Molecular Medicine 18(5). p.248-255- Abstract
- α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures. Recent studies have shown that α-syn can be transmitted between neurons and can seed the formation of toxic aggregates in recipient neurons in a prion-like manner. In addition, it is known that Lewy body pathology may spread gradually and systematically from the peripheral or enteric nervous system or olfactory bulb to specific brain regions during progression of idiopathic PD. It is therefore conceivable that α-syn species could act as seeds that drive PD progression. Here, we review recent advances from studies of α-syn cell-to-cell transfer, the current... (More)
- α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures. Recent studies have shown that α-syn can be transmitted between neurons and can seed the formation of toxic aggregates in recipient neurons in a prion-like manner. In addition, it is known that Lewy body pathology may spread gradually and systematically from the peripheral or enteric nervous system or olfactory bulb to specific brain regions during progression of idiopathic PD. It is therefore conceivable that α-syn species could act as seeds that drive PD progression. Here, we review recent advances from studies of α-syn cell-to-cell transfer, the current understanding of α-syn toxicity, and how these relate to progression of PD pathology. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2519440
- author
- Hansen, Christian LU and Li, Jia-Yi LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Molecular Medicine
- volume
- 18
- issue
- 5
- pages
- 248 - 255
- publisher
- Elsevier
- external identifiers
-
- wos:000304232000002
- pmid:22503115
- scopus:84860501370
- pmid:22503115
- ISSN
- 1471-4914
- DOI
- 10.1016/j.molmed.2012.03.002
- language
- English
- LU publication?
- yes
- id
- 816abdf2-46b0-44c5-9562-878b09f3c770 (old id 2519440)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22503115?dopt=Abstract
- date added to LUP
- 2016-04-01 14:10:49
- date last changed
- 2022-04-22 01:50:35
@article{816abdf2-46b0-44c5-9562-878b09f3c770,
abstract = {{α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures. Recent studies have shown that α-syn can be transmitted between neurons and can seed the formation of toxic aggregates in recipient neurons in a prion-like manner. In addition, it is known that Lewy body pathology may spread gradually and systematically from the peripheral or enteric nervous system or olfactory bulb to specific brain regions during progression of idiopathic PD. It is therefore conceivable that α-syn species could act as seeds that drive PD progression. Here, we review recent advances from studies of α-syn cell-to-cell transfer, the current understanding of α-syn toxicity, and how these relate to progression of PD pathology.}},
author = {{Hansen, Christian and Li, Jia-Yi}},
issn = {{1471-4914}},
language = {{eng}},
number = {{5}},
pages = {{248--255}},
publisher = {{Elsevier}},
series = {{Trends in Molecular Medicine}},
title = {{Beyond α-synuclein transfer: pathology propagation in Parkinson's disease.}},
url = {{https://lup.lub.lu.se/search/files/3829212/2539401.pdf}},
doi = {{10.1016/j.molmed.2012.03.002}},
volume = {{18}},
year = {{2012}},
}