Gestational Age at Birth and Risk of Gastric Acid-Related Disorders in Young Adulthood
(2012) In Annals of Epidemiology 22(4). p.233-238- Abstract
- PURPOSE: Preterm birth is associated with gastric acid-related disorders in infancy, but no investigators have examined this association beyond early childhood. We used antisecretory medication data to explore whether preterm birth is associated with gastric acid-related disorders in young adulthood. METHODS: We conducted a national cohort study of 626,811 individuals born in Sweden in 1973 to 1979, followed up for antisecretory (proton pump inhibitor and H2-receptor antagonist) medication prescriptions from all outpatient and inpatient pharmacies nationwide from 2005 to 2009 (ages 25.5-37.0 years). We excluded individuals with congenital anomalies, and examined potential confounding by other comorbidities identified on the basis of oral... (More)
- PURPOSE: Preterm birth is associated with gastric acid-related disorders in infancy, but no investigators have examined this association beyond early childhood. We used antisecretory medication data to explore whether preterm birth is associated with gastric acid-related disorders in young adulthood. METHODS: We conducted a national cohort study of 626,811 individuals born in Sweden in 1973 to 1979, followed up for antisecretory (proton pump inhibitor and H2-receptor antagonist) medication prescriptions from all outpatient and inpatient pharmacies nationwide from 2005 to 2009 (ages 25.5-37.0 years). We excluded individuals with congenital anomalies, and examined potential confounding by other comorbidities identified on the basis of oral anti-inflammatory or corticosteroid medication prescription. RESULTS: Gestational age at birth was inversely associated with antisecretory medication prescription in young adulthood. Adjusted odds ratios for >= 1 antisecretory medication prescription/year were 3.38 (95% confidence interval [95% CI], 1.73-6.62) for individuals born at 22-27 weeks, 1.38 (95% CI, 1.19-1.60) for those born at 28-34 weeks, and 1.19 (95% CI, 1.06-1.32) for those born at 35-36 weeks, relative to those born full-term (37-42 weeks). Exclusion of individuals who were prescribed oral anti-inflammatory or corticosteroid medications (>= 1/year) had little effect on these results. CONCLUSIONS: These findings suggest that low gestational age at birth may be independently associated with an increased risk of gastric acid-related disorders in young adulthood. Ann Epidemiol 2012;22:233-238. (C) 2012 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2587563
- author
- Crump, Casey ; Winkleby, Marilyn A. ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Gastric Acid, Gastroesophageal Reflux, Gestational Age, Premature Birth
- in
- Annals of Epidemiology
- volume
- 22
- issue
- 4
- pages
- 233 - 238
- publisher
- Elsevier
- external identifiers
-
- wos:000302510100002
- scopus:84859008344
- pmid:22382080
- ISSN
- 1047-2797
- DOI
- 10.1016/j.annepidem.2012.02.006
- language
- English
- LU publication?
- yes
- id
- 98f2f4cd-3a4a-4fc1-8454-f0f405a75d78 (old id 2587563)
- date added to LUP
- 2016-04-01 09:48:02
- date last changed
- 2022-01-25 08:47:42
@article{98f2f4cd-3a4a-4fc1-8454-f0f405a75d78,
abstract = {{PURPOSE: Preterm birth is associated with gastric acid-related disorders in infancy, but no investigators have examined this association beyond early childhood. We used antisecretory medication data to explore whether preterm birth is associated with gastric acid-related disorders in young adulthood. METHODS: We conducted a national cohort study of 626,811 individuals born in Sweden in 1973 to 1979, followed up for antisecretory (proton pump inhibitor and H2-receptor antagonist) medication prescriptions from all outpatient and inpatient pharmacies nationwide from 2005 to 2009 (ages 25.5-37.0 years). We excluded individuals with congenital anomalies, and examined potential confounding by other comorbidities identified on the basis of oral anti-inflammatory or corticosteroid medication prescription. RESULTS: Gestational age at birth was inversely associated with antisecretory medication prescription in young adulthood. Adjusted odds ratios for >= 1 antisecretory medication prescription/year were 3.38 (95% confidence interval [95% CI], 1.73-6.62) for individuals born at 22-27 weeks, 1.38 (95% CI, 1.19-1.60) for those born at 28-34 weeks, and 1.19 (95% CI, 1.06-1.32) for those born at 35-36 weeks, relative to those born full-term (37-42 weeks). Exclusion of individuals who were prescribed oral anti-inflammatory or corticosteroid medications (>= 1/year) had little effect on these results. CONCLUSIONS: These findings suggest that low gestational age at birth may be independently associated with an increased risk of gastric acid-related disorders in young adulthood. Ann Epidemiol 2012;22:233-238. (C) 2012 Elsevier Inc. All rights reserved.}},
author = {{Crump, Casey and Winkleby, Marilyn A. and Sundquist, Jan and Sundquist, Kristina}},
issn = {{1047-2797}},
keywords = {{Gastric Acid; Gastroesophageal Reflux; Gestational Age; Premature Birth}},
language = {{eng}},
number = {{4}},
pages = {{233--238}},
publisher = {{Elsevier}},
series = {{Annals of Epidemiology}},
title = {{Gestational Age at Birth and Risk of Gastric Acid-Related Disorders in Young Adulthood}},
url = {{http://dx.doi.org/10.1016/j.annepidem.2012.02.006}},
doi = {{10.1016/j.annepidem.2012.02.006}},
volume = {{22}},
year = {{2012}},
}