Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Diffusion Tensor Imaging of Normal-Appearing White Matter as Biomarker for Radiation-Induced Late Delayed Cognitive Decline

Chapman, Christopher H. ; Nagesh, Vijaya ; Sundgren, Pia LU orcid ; Buchtel, Henry ; Chenevert, Thomas L. ; Junck, Larry ; Lawrence, Theodore S. ; Tsien, Christina I. and Cao, Yue (2012) In International Journal of Radiation Oncology, Biology, Physics 82(5). p.2033-2040
Abstract
Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT). Methods and Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. The diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. A quality-of-life survey and neuro-cognitive function tests were administered before and after RT at the magnetic resonance imaging follow-up visits. Results: In both structures, longitudinal... (More)
Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT). Methods and Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. The diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. A quality-of-life survey and neuro-cognitive function tests were administered before and after RT at the magnetic resonance imaging follow-up visits. Results: In both structures, longitudinal diffusivity (lambda(parallel to)) decreased and perpendicular diffusivity (lambda(perpendicular to)) increased after RT, with early changes correlating to later changes (p < .05). The radiation dose correlated with an increase in cingulum lambda(perpendicular to) at 3 weeks, and patients with >50% of cingula volume receiving >12 Gy had a greater increase in lambda(perpendicular to) at 3 and 6 weeks (p < .05). The post-RT changes in verbal recall scores correlated linearly with the late changes in cingulum lambda(parallel to) (30 weeks, p < .02). Using receiver operating characteristic curves, early cingulum lambda(parallel to) changes predicted for post-RT changes in verbal recall scores (3 and 6 weeks, p < .05). The neurocognitive test scores correlated significantly with the quality-of-life survey results. Conclusions: The correlation between early diffusivity changes in the parahippocampal cingulum and the late decline in verbal recall suggests that diffusion tensor imaging might be useful as a biomarker for predicting late delayed cognitive decline. (C) 2012 Elsevier Inc. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diffusion tensor imaging, Neurocognitive function, Late-delayed effects, Biomarker, Quality of life
in
International Journal of Radiation Oncology, Biology, Physics
volume
82
issue
5
pages
2033 - 2040
publisher
Elsevier
external identifiers
  • wos:000301891300083
  • scopus:84858708942
  • pmid:21570218
ISSN
0360-3016
DOI
10.1016/j.ijrobp.2011.01.068
language
English
LU publication?
yes
id
7e15e2a2-c181-45f9-9af5-6bf0c73491e2 (old id 2587640)
date added to LUP
2016-04-01 11:03:07
date last changed
2022-04-12 19:59:20
@article{7e15e2a2-c181-45f9-9af5-6bf0c73491e2,
  abstract     = {{Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT). Methods and Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. The diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. A quality-of-life survey and neuro-cognitive function tests were administered before and after RT at the magnetic resonance imaging follow-up visits. Results: In both structures, longitudinal diffusivity (lambda(parallel to)) decreased and perpendicular diffusivity (lambda(perpendicular to)) increased after RT, with early changes correlating to later changes (p &lt; .05). The radiation dose correlated with an increase in cingulum lambda(perpendicular to) at 3 weeks, and patients with &gt;50% of cingula volume receiving &gt;12 Gy had a greater increase in lambda(perpendicular to) at 3 and 6 weeks (p &lt; .05). The post-RT changes in verbal recall scores correlated linearly with the late changes in cingulum lambda(parallel to) (30 weeks, p &lt; .02). Using receiver operating characteristic curves, early cingulum lambda(parallel to) changes predicted for post-RT changes in verbal recall scores (3 and 6 weeks, p &lt; .05). The neurocognitive test scores correlated significantly with the quality-of-life survey results. Conclusions: The correlation between early diffusivity changes in the parahippocampal cingulum and the late decline in verbal recall suggests that diffusion tensor imaging might be useful as a biomarker for predicting late delayed cognitive decline. (C) 2012 Elsevier Inc.}},
  author       = {{Chapman, Christopher H. and Nagesh, Vijaya and Sundgren, Pia and Buchtel, Henry and Chenevert, Thomas L. and Junck, Larry and Lawrence, Theodore S. and Tsien, Christina I. and Cao, Yue}},
  issn         = {{0360-3016}},
  keywords     = {{Diffusion tensor imaging; Neurocognitive function; Late-delayed effects; Biomarker; Quality of life}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{2033--2040}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Radiation Oncology, Biology, Physics}},
  title        = {{Diffusion Tensor Imaging of Normal-Appearing White Matter as Biomarker for Radiation-Induced Late Delayed Cognitive Decline}},
  url          = {{http://dx.doi.org/10.1016/j.ijrobp.2011.01.068}},
  doi          = {{10.1016/j.ijrobp.2011.01.068}},
  volume       = {{82}},
  year         = {{2012}},
}