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Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

Axling, Ulrika LU ; Dey, Estera LU ; Holm, Cecilia LU and Degerman, Eva LU orcid (2011) In Molecular Nutrition and Food Research 55. p.290-293
Abstract
The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipose tissue, Alkylresorcinols, Lipolysis, Type 2 diabetes, Whole, grain
in
Molecular Nutrition and Food Research
volume
55
pages
290 - 293
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000303246700014
  • scopus:80053269621
  • pmid:21887818
ISSN
1613-4133
DOI
10.1002/mnfr.201100231
project
ANTIDIABETIC FOOD CENTRE
language
English
LU publication?
yes
id
e4238658-5601-4280-9c8c-6e4b7f2c710b (old id 2594765)
date added to LUP
2016-04-01 10:35:53
date last changed
2022-05-25 05:15:23
@article{e4238658-5601-4280-9c8c-6e4b7f2c710b,
  abstract     = {{The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for stimulated lipolysis, and phosphorylation of protein kinase A substrates, were diminished after preincubation with ARs, whereas HSL protein expression was unaltered. ARs were also shown to inhibit HSL activity in an in vitro assay.}},
  author       = {{Axling, Ulrika and Dey, Estera and Holm, Cecilia and Degerman, Eva}},
  issn         = {{1613-4133}},
  keywords     = {{Adipose tissue; Alkylresorcinols; Lipolysis; Type 2 diabetes; Whole; grain}},
  language     = {{eng}},
  pages        = {{290--293}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Molecular Nutrition and Food Research}},
  title        = {{Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity}},
  url          = {{http://dx.doi.org/10.1002/mnfr.201100231}},
  doi          = {{10.1002/mnfr.201100231}},
  volume       = {{55}},
  year         = {{2011}},
}