Detrusor contraction - Focus on muscarinic receptors
Andersson, Karl-Erik LU
(2004)
In Scandinavian Journal of Urology and Nephrology
38(Suppl 215).
p.54-57
- Abstract
- Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of... (More)
- Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of the detrusor may be calcium influx via L-type calcium channels, and increased sensitivity to calcium of the contractile machinery via inhibition of myosin light chain phosphatase through activation of Rho-kinase. The importance of these findings for treatment of voiding dysfunction remains to be established. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/261327
- author
- Andersson, Karl-Erik
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sensitivity, calcium, contractile proteins, bladder, signal transduction, acetylcholine
- in
- Scandinavian Journal of Urology and Nephrology
- volume
- 38
- issue
- Suppl 215
- pages
- 54 - 57
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000224980100007
- scopus:9244260506
- ISSN
- 0036-5599
- DOI
- 10.1080/03008880410015192
- language
- English
- LU publication?
- yes
- id
- 74ba4ae4-c785-4db1-8d90-42969bb15c93 (old id 261327)
- date added to LUP
- 2016-04-01 15:27:07
- date last changed
- 2022-02-12 08:00:25
@article{74ba4ae4-c785-4db1-8d90-42969bb15c93,
abstract = {{Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of the detrusor may be calcium influx via L-type calcium channels, and increased sensitivity to calcium of the contractile machinery via inhibition of myosin light chain phosphatase through activation of Rho-kinase. The importance of these findings for treatment of voiding dysfunction remains to be established.}},
author = {{Andersson, Karl-Erik}},
issn = {{0036-5599}},
keywords = {{sensitivity; calcium; contractile proteins; bladder; signal transduction; acetylcholine}},
language = {{eng}},
number = {{Suppl 215}},
pages = {{54--57}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Urology and Nephrology}},
title = {{Detrusor contraction - Focus on muscarinic receptors}},
url = {{http://dx.doi.org/10.1080/03008880410015192}},
doi = {{10.1080/03008880410015192}},
volume = {{38}},
year = {{2004}},
}