Epidemiological evidence on reproductive effects of persistent organochlorines in humans
(2004) In Reproductive Toxicology 19(1). p.5-26- Abstract
- Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day... (More)
- Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health. (C) 2004 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/266664
- author
- Toft, G ; Hagmar, L ; Giwercman, Aleksander LU and Bonde, JP
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- endocrine disruption, fertility, reproduction, DDE, DDT, organochlorines, PCB, human
- in
- Reproductive Toxicology
- volume
- 19
- issue
- 1
- pages
- 5 - 26
- publisher
- Elsevier
- external identifiers
-
- wos:000224020900003
- pmid:15336708
- scopus:4444312867
- ISSN
- 1873-1708
- DOI
- 10.1016/j.reprotox.2004.05.006
- language
- English
- LU publication?
- yes
- id
- b5522ea9-e435-4e54-82b1-140a7e8cc8b6 (old id 266664)
- date added to LUP
- 2016-04-01 15:41:45
- date last changed
- 2022-05-16 00:23:24
@article{b5522ea9-e435-4e54-82b1-140a7e8cc8b6, abstract = {{Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies. Recently, this issue has been addressed by a number of studies of exposed populations and hospital-based case-referent studies. These studies indicate that high concentrations of persistent organochlorines may adversely affect semen quality and cause testicular cancer in males, induce menstrual cycle abnormalities and spontaneous abortions in females, and cause prolonged waiting time pregnancy, reduced birth weight, skewed sex ratio, and altered age of sexual development. However, most effects have been demonstrated at exposure levels above the present day exposure level in European and North American populations. Due to inherent methodological problems in several of the available studies, additional research is needed to fully elucidate the possible adverse effects of organochlorines on human reproductive health. (C) 2004 Elsevier Inc. All rights reserved.}}, author = {{Toft, G and Hagmar, L and Giwercman, Aleksander and Bonde, JP}}, issn = {{1873-1708}}, keywords = {{endocrine disruption; fertility; reproduction; DDE; DDT; organochlorines; PCB; human}}, language = {{eng}}, number = {{1}}, pages = {{5--26}}, publisher = {{Elsevier}}, series = {{Reproductive Toxicology}}, title = {{Epidemiological evidence on reproductive effects of persistent organochlorines in humans}}, url = {{http://dx.doi.org/10.1016/j.reprotox.2004.05.006}}, doi = {{10.1016/j.reprotox.2004.05.006}}, volume = {{19}}, year = {{2004}}, }