Oxidized Dextran as Crosslinker for Chitosan Cryogel Scaffolds and Formation of Polyelectrolyte Complexes between Chitosan and Gelatin.
(2012) In Macromolecular Bioscience 12(8). p.1090-1099- Abstract
- Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectrolyte complexes between chitosan and gelatin before crosslinking takes place. The scaffolds exhibit highly elastic properties withstanding compressions up to 60%. The in vitro biocompatibility of the cryogels is evaluated using fibroblasts from a mouse cell line (L929) and it is seen that the cells adhere and proliferate on the scaffolds. The mesoporous structure seems to have a positive effect... (More)
- Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectrolyte complexes between chitosan and gelatin before crosslinking takes place. The scaffolds exhibit highly elastic properties withstanding compressions up to 60%. The in vitro biocompatibility of the cryogels is evaluated using fibroblasts from a mouse cell line (L929) and it is seen that the cells adhere and proliferate on the scaffolds. The mesoporous structure seems to have a positive effect on proliferation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2859716
- author
- Berillo, Dmitriy ; Elowsson, Linda LU and Kirsebom, Harald
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Macromolecular Bioscience
- volume
- 12
- issue
- 8
- pages
- 1090 - 1099
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000307218500011
- pmid:22674878
- scopus:84864797942
- pmid:22674878
- ISSN
- 1616-5195
- DOI
- 10.1002/mabi.201200023
- language
- English
- LU publication?
- yes
- id
- 04d3ae23-8f40-46cb-8548-4ced696994ad (old id 2859716)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22674878?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:25
- date last changed
- 2022-03-07 22:33:39
@article{04d3ae23-8f40-46cb-8548-4ced696994ad,
abstract = {{Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectrolyte complexes between chitosan and gelatin before crosslinking takes place. The scaffolds exhibit highly elastic properties withstanding compressions up to 60%. The in vitro biocompatibility of the cryogels is evaluated using fibroblasts from a mouse cell line (L929) and it is seen that the cells adhere and proliferate on the scaffolds. The mesoporous structure seems to have a positive effect on proliferation.}},
author = {{Berillo, Dmitriy and Elowsson, Linda and Kirsebom, Harald}},
issn = {{1616-5195}},
language = {{eng}},
number = {{8}},
pages = {{1090--1099}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Macromolecular Bioscience}},
title = {{Oxidized Dextran as Crosslinker for Chitosan Cryogel Scaffolds and Formation of Polyelectrolyte Complexes between Chitosan and Gelatin.}},
url = {{http://dx.doi.org/10.1002/mabi.201200023}},
doi = {{10.1002/mabi.201200023}},
volume = {{12}},
year = {{2012}},
}