Stem cell-based therapy for malignant glioma.
(2013) In Cancer Treatment Reviews 39(4). p.358-365- Abstract
- Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the... (More)
- Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the contribution of stem cells to the pro-tumourigenic stroma, and the malignant transformation of implanted stem cells. In addition, it is not yet known which stem cell types and therapeutic genes will be most effective for the treatment of glioma patients. Here, we highlight the possibilities and problems for translating promising experimental findings in glioma models into the clinic. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2967156
- author
- Bexell, Daniel LU ; Svensson, Andreas LU and Bengzon, Johan LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Treatment Reviews
- volume
- 39
- issue
- 4
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- wos:000317709300007
- pmid:22795538
- scopus:84875503789
- ISSN
- 1532-1967
- DOI
- 10.1016/j.ctrv.2012.06.006
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurosurgery (013026000), Molecular Medicine (013031200)
- id
- d91af2f4-fcb7-4314-afb9-e9da2918df6f (old id 2967156)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22795538?dopt=Abstract
- date added to LUP
- 2016-04-01 11:07:33
- date last changed
- 2022-04-05 00:16:43
@article{d91af2f4-fcb7-4314-afb9-e9da2918df6f,
abstract = {{Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the contribution of stem cells to the pro-tumourigenic stroma, and the malignant transformation of implanted stem cells. In addition, it is not yet known which stem cell types and therapeutic genes will be most effective for the treatment of glioma patients. Here, we highlight the possibilities and problems for translating promising experimental findings in glioma models into the clinic.}},
author = {{Bexell, Daniel and Svensson, Andreas and Bengzon, Johan}},
issn = {{1532-1967}},
language = {{eng}},
number = {{4}},
pages = {{358--365}},
publisher = {{Elsevier}},
series = {{Cancer Treatment Reviews}},
title = {{Stem cell-based therapy for malignant glioma.}},
url = {{https://lup.lub.lu.se/search/files/2399225/3436776.pdf}},
doi = {{10.1016/j.ctrv.2012.06.006}},
volume = {{39}},
year = {{2013}},
}