Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.
Hindy, George LU ; Sonestedt, Emily LU
; Ericson, Ulrika
LU
; Jing, X-J
; Zhou, Yuedan
LU
; Hansson, Ola
LU
; Renström, Erik
LU
; Wirfält, Elisabet
LU
and Orho-Melander, Marju
LU
(2012)
In Diabetologia
55(10).
p.2646-2654
- Abstract
- AIMS/HYPOTHESIS:
The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes.
METHODS:
A cohort of 24,799 non-diabetic individuals from the Malmö Diet and Cancer Study (MDCS), with dietary data obtained by a modified diet history method, were followed up for 12 years, with 1,649 recordings of incident type 2 diabetes made. Risk of type 2 diabetes in strata of diet quintiles was analysed prospectively adjusting for... (More) - AIMS/HYPOTHESIS:
The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes.
METHODS:
A cohort of 24,799 non-diabetic individuals from the Malmö Diet and Cancer Study (MDCS), with dietary data obtained by a modified diet history method, were followed up for 12 years, with 1,649 recordings of incident type 2 diabetes made. Risk of type 2 diabetes in strata of diet quintiles was analysed prospectively adjusting for potential confounders. Cross-sectional analyses were performed on baseline fasting glucose and HbA(1c) levels in a subset of 5,216 randomly selected individuals from the MDCS.
RESULTS:
The elevated risk of type 2 diabetes with rs7903146 (OR 1.44, 95% CI 1.33, 1.56, p = 4.6 × 10(-19)) increased with higher intake of dietary fibre (OR 1.24, 95% CI 1.04, 1.47 to OR 1.56, 95% CI 1.31, 1.86 from the lowest to highest quintile; p (interaction) = 0.049). High intake of dietary fibre was inversely associated with diabetes incidence only among CC genotype carriers (OR 0.74, 95% CI 0.58, 0.94 per quintile, p = 0.025). The T allele was associated with 0.027% elevated HbA(1c) (p = 0.02) and this effect increased with higher intake of fibre (from -0.021% to 0.079% for the lowest to the highest quintile, p (interaction) = 0.02). Each quintile of higher fibre intake was associated with lower HbA(1c) levels among CC and CT but not among TT genotype carriers (-0.036%, p = 6.5 × 10(-7); -0.023%, p = 0.009; and 0.012%, p = 0.52, respectively).
CONCLUSIONS/INTERPRETATION:
Our study suggests that dietary fibre intake may modify the association between TCF7L2 rs7903146 and incidence of type 2 diabetes, and that higher fibre intake may associate with protection from type 2 diabetes only among non-risk allele carriers. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2967274
- author
- Hindy, George
LU
; Sonestedt, Emily
LU
; Ericson, Ulrika
LU
; Jing, X-J
; Zhou, Yuedan
LU
; Hansson, Ola
LU
; Renström, Erik
LU
; Wirfält, Elisabet
LU
and Orho-Melander, Marju
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetologia
- volume
- 55
- issue
- 10
- pages
- 2646 - 2654
- publisher
- Springer
- external identifiers
-
- wos:000308354600013
- pmid:22782288
- scopus:84866089891
- pmid:22782288
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-012-2634-x
- language
- English
- LU publication?
- yes
- id
- cf9f390d-39e2-4207-92a5-95f7fe312e60 (old id 2967274)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22782288?dopt=Abstract
- date added to LUP
- 2016-04-04 08:10:20
- date last changed
- 2024-02-27 18:33:28
@article{cf9f390d-39e2-4207-92a5-95f7fe312e60,
abstract = {{AIMS/HYPOTHESIS: <br/><br>
The T allele of transcription factor 7-like 2 gene variant, TCF7L2 rs7903146, increases the risk of type 2 diabetes by 40-50%. As TCF7L2 rs7903146 has been associated with diminished incretin effect we investigated whether interaction between dietary intake of carbohydrate, fat, protein or fibre and this variant affects the risk of type 2 diabetes. <br/><br>
<br/><br>
METHODS: <br/><br>
A cohort of 24,799 non-diabetic individuals from the Malmö Diet and Cancer Study (MDCS), with dietary data obtained by a modified diet history method, were followed up for 12 years, with 1,649 recordings of incident type 2 diabetes made. Risk of type 2 diabetes in strata of diet quintiles was analysed prospectively adjusting for potential confounders. Cross-sectional analyses were performed on baseline fasting glucose and HbA(1c) levels in a subset of 5,216 randomly selected individuals from the MDCS. <br/><br>
<br/><br>
RESULTS: <br/><br>
The elevated risk of type 2 diabetes with rs7903146 (OR 1.44, 95% CI 1.33, 1.56, p = 4.6 × 10(-19)) increased with higher intake of dietary fibre (OR 1.24, 95% CI 1.04, 1.47 to OR 1.56, 95% CI 1.31, 1.86 from the lowest to highest quintile; p (interaction) = 0.049). High intake of dietary fibre was inversely associated with diabetes incidence only among CC genotype carriers (OR 0.74, 95% CI 0.58, 0.94 per quintile, p = 0.025). The T allele was associated with 0.027% elevated HbA(1c) (p = 0.02) and this effect increased with higher intake of fibre (from -0.021% to 0.079% for the lowest to the highest quintile, p (interaction) = 0.02). Each quintile of higher fibre intake was associated with lower HbA(1c) levels among CC and CT but not among TT genotype carriers (-0.036%, p = 6.5 × 10(-7); -0.023%, p = 0.009; and 0.012%, p = 0.52, respectively). <br/><br>
<br/><br>
CONCLUSIONS/INTERPRETATION: <br/><br>
Our study suggests that dietary fibre intake may modify the association between TCF7L2 rs7903146 and incidence of type 2 diabetes, and that higher fibre intake may associate with protection from type 2 diabetes only among non-risk allele carriers.}},
author = {{Hindy, George and Sonestedt, Emily and Ericson, Ulrika and Jing, X-J and Zhou, Yuedan and Hansson, Ola and Renström, Erik and Wirfält, Elisabet and Orho-Melander, Marju}},
issn = {{1432-0428}},
language = {{eng}},
number = {{10}},
pages = {{2646--2654}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.}},
url = {{http://dx.doi.org/10.1007/s00125-012-2634-x}},
doi = {{10.1007/s00125-012-2634-x}},
volume = {{55}},
year = {{2012}},
}