Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy.
(2012) In Viral Immunology 25(4). p.254-261- Abstract
- Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA), in early pregnancy and at delivery were compared to islet autoantibody-negative mothers (n=1457) matched for age and sampling date. Mothers were genotyped for HLA-DQ and analyzed for both EV-RNA and EV-IgM. EV-IgM, but not EV-RNA, was detected during early... (More)
- Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA), in early pregnancy and at delivery were compared to islet autoantibody-negative mothers (n=1457) matched for age and sampling date. Mothers were genotyped for HLA-DQ and analyzed for both EV-RNA and EV-IgM. EV-IgM, but not EV-RNA, was detected during early pregnancy in 12% of islet autoantibody-positive mothers compared to 11% of the controls. In early pregnancy, mothers with HLA-DQ 2/2 or 2/X genotypes showed an increased risk for islet autoantibodies at delivery (OR 1.85; p=0.001). After adjusting for parity, maternal age, year of birth, and season of early pregnancy, early pregnancy EV-IgM combined with DQ2/2 or 2/X increased the risk for islet autoantibodies (OR 3.10; 95% CI 1; p=0.008). EV-IgM in early pregnancy increased the risk for islet autoantibodies at delivery in non-diabetic mothers with HLA-DQ 2/2 or 2/X type 1 diabetes risk genotypes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2967697
- author
- Rešić Lindehammer, Sabina ; Honkanen, Hanna ; Nix, William Allan ; Oikarinen, Maarit ; Lynch, Kristian LU ; Jönsson, Ida LU ; Marsal, Karel LU ; Oberste, Steven ; Hyöty, Heikki and Lernmark, Åke LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Viral Immunology
- volume
- 25
- issue
- 4
- pages
- 254 - 261
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- wos:000307729400004
- pmid:22746839
- scopus:84865010272
- pmid:22746839
- ISSN
- 0882-8245
- DOI
- 10.1089/vim.2012.0022
- language
- English
- LU publication?
- yes
- id
- a35515ee-b787-4b0a-99f8-d0fea176e48f (old id 2967697)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22746839?dopt=Abstract
- date added to LUP
- 2016-04-01 13:12:50
- date last changed
- 2022-04-21 20:24:16
@article{a35515ee-b787-4b0a-99f8-d0fea176e48f, abstract = {{Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA), in early pregnancy and at delivery were compared to islet autoantibody-negative mothers (n=1457) matched for age and sampling date. Mothers were genotyped for HLA-DQ and analyzed for both EV-RNA and EV-IgM. EV-IgM, but not EV-RNA, was detected during early pregnancy in 12% of islet autoantibody-positive mothers compared to 11% of the controls. In early pregnancy, mothers with HLA-DQ 2/2 or 2/X genotypes showed an increased risk for islet autoantibodies at delivery (OR 1.85; p=0.001). After adjusting for parity, maternal age, year of birth, and season of early pregnancy, early pregnancy EV-IgM combined with DQ2/2 or 2/X increased the risk for islet autoantibodies (OR 3.10; 95% CI 1; p=0.008). EV-IgM in early pregnancy increased the risk for islet autoantibodies at delivery in non-diabetic mothers with HLA-DQ 2/2 or 2/X type 1 diabetes risk genotypes.}}, author = {{Rešić Lindehammer, Sabina and Honkanen, Hanna and Nix, William Allan and Oikarinen, Maarit and Lynch, Kristian and Jönsson, Ida and Marsal, Karel and Oberste, Steven and Hyöty, Heikki and Lernmark, Åke}}, issn = {{0882-8245}}, language = {{eng}}, number = {{4}}, pages = {{254--261}}, publisher = {{Mary Ann Liebert, Inc.}}, series = {{Viral Immunology}}, title = {{Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy.}}, url = {{https://lup.lub.lu.se/search/files/3232989/3460958.pdf}}, doi = {{10.1089/vim.2012.0022}}, volume = {{25}}, year = {{2012}}, }