The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
(2003) In Neuron 40(2). p.427-446- Abstract
- The ubiquitin-proteasome system targets numerous cellular proteins for degradation. In addition, modifications by ubiquitin-like proteins as well as proteins containing ubiquitin-interacting and -associated motifs modulate many others. This tightly controlled process involves multiple specific and general enzymes of the system as well as many modifying and ancillary proteins. Thus, it is not surprising that ubiquitin-mediated degradation/processing/modification regulates a broad array of basic cellular processes. Moreover, aberrations in the system have been implicated, either as a primary cause or secondary consequence, in the pathogenesis of both inherited and acquired neurodegenerative diseases. Recent findings indicate that the system... (More)
- The ubiquitin-proteasome system targets numerous cellular proteins for degradation. In addition, modifications by ubiquitin-like proteins as well as proteins containing ubiquitin-interacting and -associated motifs modulate many others. This tightly controlled process involves multiple specific and general enzymes of the system as well as many modifying and ancillary proteins. Thus, it is not surprising that ubiquitin-mediated degradation/processing/modification regulates a broad array of basic cellular processes. Moreover, aberrations in the system have been implicated, either as a primary cause or secondary consequence, in the pathogenesis of both inherited and acquired neurodegenerative diseases. Recent findings indicate that the system is involved in the pathogenesis of Parkinson's, Alzheimer's, Huntington's, and Prion diseases as well as amyotrophic lateral sclerosis. This raises hopes for a better understanding of the pathogenetic mechanisms involved in these diseases and for the development of novel, mechanism-based therapeutic modalities. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/298603
- author
- Ciechanover, A and Brundin, Patrik LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuron
- volume
- 40
- issue
- 2
- pages
- 427 - 446
- publisher
- Cell Press
- external identifiers
-
- wos:000185875800017
- pmid:14556719
- scopus:0141987860
- ISSN
- 0896-6273
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- 085a2e9e-897d-4753-8072-91d0e7811426 (old id 298603)
- alternative location
- http://www.neuron.org/content/article/abstract?uid=PIIS0896627303006068
- date added to LUP
- 2016-04-01 12:04:07
- date last changed
- 2022-04-29 00:07:02
@article{085a2e9e-897d-4753-8072-91d0e7811426,
abstract = {{The ubiquitin-proteasome system targets numerous cellular proteins for degradation. In addition, modifications by ubiquitin-like proteins as well as proteins containing ubiquitin-interacting and -associated motifs modulate many others. This tightly controlled process involves multiple specific and general enzymes of the system as well as many modifying and ancillary proteins. Thus, it is not surprising that ubiquitin-mediated degradation/processing/modification regulates a broad array of basic cellular processes. Moreover, aberrations in the system have been implicated, either as a primary cause or secondary consequence, in the pathogenesis of both inherited and acquired neurodegenerative diseases. Recent findings indicate that the system is involved in the pathogenesis of Parkinson's, Alzheimer's, Huntington's, and Prion diseases as well as amyotrophic lateral sclerosis. This raises hopes for a better understanding of the pathogenetic mechanisms involved in these diseases and for the development of novel, mechanism-based therapeutic modalities.}},
author = {{Ciechanover, A and Brundin, Patrik}},
issn = {{0896-6273}},
language = {{eng}},
number = {{2}},
pages = {{427--446}},
publisher = {{Cell Press}},
series = {{Neuron}},
title = {{The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg}},
url = {{http://www.neuron.org/content/article/abstract?uid=PIIS0896627303006068}},
volume = {{40}},
year = {{2003}},
}