The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight
(2012) In Obesity 20(11). p.2257-2261- Abstract
- The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and obesity. Twenty overweight or obese children and twenty children with body mass index within the normal range (age: 4-5 years) were recruited from the south of Sweden. The gut microbiota was accessed by quantitative polymerase chain reactions and terminal restriction fragment length polymorphism and calprotectin was measured in faeces. Liver enzymes were quantified in obese/overweight children. The concentration of the Gram-negative family Enterobacteriaceae was significantly higher in the obese/overweight children (P=0.036) while levels of Desulfovibrio and Akkermansia muciniphila-like bacteria were significantly lower in the... (More)
- The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and obesity. Twenty overweight or obese children and twenty children with body mass index within the normal range (age: 4-5 years) were recruited from the south of Sweden. The gut microbiota was accessed by quantitative polymerase chain reactions and terminal restriction fragment length polymorphism and calprotectin was measured in faeces. Liver enzymes were quantified in obese/overweight children. The concentration of the Gram-negative family Enterobacteriaceae was significantly higher in the obese/overweight children (P=0.036) while levels of Desulfovibrio and Akkermansia muciniphila-like bacteria were significantly lower in the obese/overweight children (P=0.027 and P=0.030, respectively). No significant differences were found in content of Lactobacillus, Bifidobacterium or the Bacteroides fragilis group. The diversity of the dominating bacterial community tended to be less diverse in the obese/overweight group, but the difference was not statistically significant. Concentration of Bifidobacterium was inversely correlated to alanine aminotransferase in obese/overweight children. The faecal levels of calprotectin did not differ between the study groups. These findings indicate that the gut microbiota differed among preschool children with obesity/overweight compared with children with body mass index within the normal range. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/29c959b8-4850-43fc-9e10-d2b16f3f55ca
- author
- Linninge, Caroline LU ; Önnerfält, Jenny LU ; Xu, Jie LU ; Molin, Göran LU ; Ahrné, Siv LU and Thorngren-Jerneck, Kristina LU
- organization
- publishing date
- 2012-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Obesity
- volume
- 20
- issue
- 11
- pages
- 2257 - 2261
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:84868197954
- wos:000310492200013
- pmid:22546742
- ISSN
- 1930-739X
- DOI
- 10.1038/oby.2012.110
- language
- English
- LU publication?
- yes
- id
- 29c959b8-4850-43fc-9e10-d2b16f3f55ca
- date added to LUP
- 2016-10-03 21:09:34
- date last changed
- 2023-12-21 00:04:56
@article{29c959b8-4850-43fc-9e10-d2b16f3f55ca,
abstract = {{The aim of this study was to investigate the gut microbiota in preschool children with and without overweight and obesity. Twenty overweight or obese children and twenty children with body mass index within the normal range (age: 4-5 years) were recruited from the south of Sweden. The gut microbiota was accessed by quantitative polymerase chain reactions and terminal restriction fragment length polymorphism and calprotectin was measured in faeces. Liver enzymes were quantified in obese/overweight children. The concentration of the Gram-negative family Enterobacteriaceae was significantly higher in the obese/overweight children (P=0.036) while levels of Desulfovibrio and Akkermansia muciniphila-like bacteria were significantly lower in the obese/overweight children (P=0.027 and P=0.030, respectively). No significant differences were found in content of Lactobacillus, Bifidobacterium or the Bacteroides fragilis group. The diversity of the dominating bacterial community tended to be less diverse in the obese/overweight group, but the difference was not statistically significant. Concentration of Bifidobacterium was inversely correlated to alanine aminotransferase in obese/overweight children. The faecal levels of calprotectin did not differ between the study groups. These findings indicate that the gut microbiota differed among preschool children with obesity/overweight compared with children with body mass index within the normal range.}},
author = {{Linninge, Caroline and Önnerfält, Jenny and Xu, Jie and Molin, Göran and Ahrné, Siv and Thorngren-Jerneck, Kristina}},
issn = {{1930-739X}},
language = {{eng}},
number = {{11}},
pages = {{2257--2261}},
publisher = {{Nature Publishing Group}},
series = {{Obesity}},
title = {{The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight}},
url = {{http://dx.doi.org/10.1038/oby.2012.110}},
doi = {{10.1038/oby.2012.110}},
volume = {{20}},
year = {{2012}},
}