Epigenetic alterations as biomarkers in pancreatic ductal adenocarcinoma
Syren, Pascal ; Andersson, Roland LU ; Bauden, Monika LU
and Ansari, Daniel
LU
(2017)
In Scandinavian Journal of Gastroenterology
52(6-7).
p.668-673
- Abstract
Pancreatic ductal adenocarcinoma (PDAC) prognosis remains very poor and has only marginally improved during the last decades. Epigenetic alterations have been the focus of many recent studies and offer valuable options for PDAC detection, prognosis and treatment. DNA methylation, histone modifications and microRNA (miR) level changes can be used as biomarkers. These alterations occur early in carcinogenesis and may be specific for PDAC. Additionally, epigenetic alterations can be analyzed from cell-free DNA, free-circulating nucleosomes or shed tumor cells in blood. High-throughput methods are available for miR and DNA methylation level detection. In particular, multiple promising miR level changes have been discovered. No single... (More)
Pancreatic ductal adenocarcinoma (PDAC) prognosis remains very poor and has only marginally improved during the last decades. Epigenetic alterations have been the focus of many recent studies and offer valuable options for PDAC detection, prognosis and treatment. DNA methylation, histone modifications and microRNA (miR) level changes can be used as biomarkers. These alterations occur early in carcinogenesis and may be specific for PDAC. Additionally, epigenetic alterations can be analyzed from cell-free DNA, free-circulating nucleosomes or shed tumor cells in blood. High-throughput methods are available for miR and DNA methylation level detection. In particular, multiple promising miR level changes have been discovered. No single epigenetic biomarker that offers a sufficient specificity has been discovered yet, but patterns containing multiple independent biomarkers exist.
(Less)
- author
- Syren, Pascal
; Andersson, Roland
LU
; Bauden, Monika
LU
and Ansari, Daniel
LU
- organization
- publishing date
- 2017-07-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biomarkers, diagnosis, DNA methylation, epigenetics, histone modifications, microRNA, Pancreatic cancer
- in
- Scandinavian Journal of Gastroenterology
- volume
- 52
- issue
- 6-7
- pages
- 668 - 673
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:28301276
- wos:000399808100009
- scopus:85018657425
- ISSN
- 0036-5521
- DOI
- 10.1080/00365521.2017.1301989
- language
- English
- LU publication?
- yes
- id
- 2ad5a947-4228-4a4d-9b8a-db7bf50731fb
- date added to LUP
- 2017-06-07 15:08:48
- date last changed
- 2024-01-13 22:18:26
@article{2ad5a947-4228-4a4d-9b8a-db7bf50731fb,
abstract = {{<p>Pancreatic ductal adenocarcinoma (PDAC) prognosis remains very poor and has only marginally improved during the last decades. Epigenetic alterations have been the focus of many recent studies and offer valuable options for PDAC detection, prognosis and treatment. DNA methylation, histone modifications and microRNA (miR) level changes can be used as biomarkers. These alterations occur early in carcinogenesis and may be specific for PDAC. Additionally, epigenetic alterations can be analyzed from cell-free DNA, free-circulating nucleosomes or shed tumor cells in blood. High-throughput methods are available for miR and DNA methylation level detection. In particular, multiple promising miR level changes have been discovered. No single epigenetic biomarker that offers a sufficient specificity has been discovered yet, but patterns containing multiple independent biomarkers exist.</p>}},
author = {{Syren, Pascal and Andersson, Roland and Bauden, Monika and Ansari, Daniel}},
issn = {{0036-5521}},
keywords = {{biomarkers; diagnosis; DNA methylation; epigenetics; histone modifications; microRNA; Pancreatic cancer}},
language = {{eng}},
month = {{07}},
number = {{6-7}},
pages = {{668--673}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Gastroenterology}},
title = {{Epigenetic alterations as biomarkers in pancreatic ductal adenocarcinoma}},
url = {{http://dx.doi.org/10.1080/00365521.2017.1301989}},
doi = {{10.1080/00365521.2017.1301989}},
volume = {{52}},
year = {{2017}},
}