Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years

Zaigham, Mehreen; Källén, Karin; Maršál, Karel; Olofsson, Per

Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years

Mark

; Källén, Karin ^LU ; Maršál, Karel ^LU and Olofsson, Per ^LU (2020) In Acta Paediatrica, International Journal of Paediatrics 109(1). p.85-92

Abstract: Aim: It is not clear whether perinatal acidosis can predict poor outcomes in extremely preterm infants and we investigated associations between intrapartum hypoxia and mortality and neurodevelopmental outcomes. Methods: We used nationwide data on 705 infants from the Extremely Preterm Infants in Sweden Study, delivered at 22-26 weeks of gestation during 2004-2007. Comprehensive neurodevelopmental assessments were performed on survivors at 2.5 (n = 456) and 6.5 (n = 441) years of corrected age. Gestational age-related changes in umbilical cord arterial pH were compared with reference values for term newborn infants, and base excess was also calculated. Associations between low blood gas values (<10th percentile) and mortality and... (More); Aim: It is not clear whether perinatal acidosis can predict poor outcomes in extremely preterm infants and we investigated associations between intrapartum hypoxia and mortality and neurodevelopmental outcomes. Methods: We used nationwide data on 705 infants from the Extremely Preterm Infants in Sweden Study, delivered at 22-26 weeks of gestation during 2004-2007. Comprehensive neurodevelopmental assessments were performed on survivors at 2.5 (n = 456) and 6.5 (n = 441) years of corrected age. Gestational age-related changes in umbilical cord arterial pH were compared with reference values for term newborn infants, and base excess was also calculated. Associations between low blood gas values (<10th percentile) and mortality and neurodevelopmental outcome were estimated. Results: Cord blood determination was more common in surviving infants (P <.001), with pH determined in 322/705 (46%) and base excess in 311/705 (44%). Extremely preterm infants had higher pH values than term infants (P <.0001), with no change from 22 to 26 weeks of gestation (P =.61, r² =.001). Multiple logistic regression showed no association between low blood gas values and risk of death or neurodevelopmental impairment at 6.5 years (P ≥.17). Conclusion: Hypoxia with acidosis at birth was not associated with an increased risk of death or impaired neurodevelopmental in extremely preterm born children at 6.5 years.
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Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/31ec1e60-bb5f-45fa-a4bb-d2838594d357

author

Zaigham, Mehreen ^LU

; Källén, Karin ^LU ; Maršál, Karel ^LU and Olofsson, Per ^LU

organization

publishing date

2020-01

type

Contribution to journal

publication status

published

subject

Pediatrics

keywords

acidosis, extremely preterm infants, mortality, neurodevelopmental outcome, umbilical cord blood gases

in

Acta Paediatrica, International Journal of Paediatrics

volume

109

issue

1

pages

8 pages

publisher

Wiley-Blackwell

external identifiers

pmid:31265156
scopus:85070072005

ISSN

0803-5253

DOI

10.1111/apa.14925

language

English

LU publication?

yes

id

31ec1e60-bb5f-45fa-a4bb-d2838594d357

date added to LUP

2019-08-22 14:02:02

date last changed

2024-04-16 17:40:32

@article{31ec1e60-bb5f-45fa-a4bb-d2838594d357,
  abstract     = {{<p>Aim: It is not clear whether perinatal acidosis can predict poor outcomes in extremely preterm infants and we investigated associations between intrapartum hypoxia and mortality and neurodevelopmental outcomes. Methods: We used nationwide data on 705 infants from the Extremely Preterm Infants in Sweden Study, delivered at 22-26 weeks of gestation during 2004-2007. Comprehensive neurodevelopmental assessments were performed on survivors at 2.5 (n = 456) and 6.5 (n = 441) years of corrected age. Gestational age-related changes in umbilical cord arterial pH were compared with reference values for term newborn infants, and base excess was also calculated. Associations between low blood gas values (&lt;10th percentile) and mortality and neurodevelopmental outcome were estimated. Results: Cord blood determination was more common in surviving infants (P &lt;.001), with pH determined in 322/705 (46%) and base excess in 311/705 (44%). Extremely preterm infants had higher pH values than term infants (P &lt;.0001), with no change from 22 to 26 weeks of gestation (P =.61, r<sup>2</sup> =.001). Multiple logistic regression showed no association between low blood gas values and risk of death or neurodevelopmental impairment at 6.5 years (P ≥.17). Conclusion: Hypoxia with acidosis at birth was not associated with an increased risk of death or impaired neurodevelopmental in extremely preterm born children at 6.5 years.</p>}},
  author       = {{Zaigham, Mehreen and Källén, Karin and Maršál, Karel and Olofsson, Per}},
  issn         = {{0803-5253}},
  keywords     = {{acidosis; extremely preterm infants; mortality; neurodevelopmental outcome; umbilical cord blood gases}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{85--92}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics}},
  title        = {{Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years}},
  url          = {{http://dx.doi.org/10.1111/apa.14925}},
  doi          = {{10.1111/apa.14925}},
  volume       = {{109}},
  year         = {{2020}},
}

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Hypoxia with acidosis in extremely preterm born infants was not associated with an increased risk of death or impaired neurodevelopmental outcome at 6.5 years