Mass transfer effects on the reaction rate for heterogeneously distributed immobilized yeast cells
(2002) In Biotechnology and Bioengineering 79(6). p.664-673- Abstract
- Here we examine the efficiency of different immobilized cell gradients applied to immobilized Saccharomyces cerevisiae fermenting glucose to ethanol. We developed a simulation model to fully study the competing effects of mass transfer hindrance and kinetics. It is based on a diffusion-reaction model and can be used to analyze the different cell concentration profiles inside an immobilized gel bead, in terms of effectiveness factors, productivity, and mass flux. The internal diffusion coefficient, which varies with the local cell concentration, as well as the external mass transfer, is taken into account when describing the efficiency. Although the diffusion hindrance is greater at higher cell concentrations, high cell concentration is... (More)
- Here we examine the efficiency of different immobilized cell gradients applied to immobilized Saccharomyces cerevisiae fermenting glucose to ethanol. We developed a simulation model to fully study the competing effects of mass transfer hindrance and kinetics. It is based on a diffusion-reaction model and can be used to analyze the different cell concentration profiles inside an immobilized gel bead, in terms of effectiveness factors, productivity, and mass flux. The internal diffusion coefficient, which varies with the local cell concentration, as well as the external mass transfer, is taken into account when describing the efficiency. Although the diffusion hindrance is greater at higher cell concentrations, high cell concentration is still advantageous in the present case because the increase in reaction rate outweighs the diffusion hindrance. Thus, high cell concentrations contribute to increased productivity. The influence of the cell concentration gradient on the efficiency of the beads is negligible, Within the range of cell profiles studied it has been established that the location of the cells within the bead is of lesser importance. However, a steep cell gradient increases the importance of the external mass transfer. (C) 2002 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/331096
- author
- Gutenwik, Jan LU ; Nilsson, Bernt LU and Axelsson, Anders LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cell concentration gradient, variable, simulation, immobilized yeast cells, diffusion, mass transfer
- in
- Biotechnology and Bioengineering
- volume
- 79
- issue
- 6
- pages
- 664 - 673
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000177549400010
- pmid:12209814
- scopus:0037144087
- ISSN
- 1097-0290
- DOI
- 10.1002/bit.10329
- language
- English
- LU publication?
- yes
- id
- c82c2fb6-970a-4fff-bbd8-5f2420ee6ab7 (old id 331096)
- date added to LUP
- 2016-04-01 11:41:30
- date last changed
- 2023-09-01 03:31:12
@article{c82c2fb6-970a-4fff-bbd8-5f2420ee6ab7,
abstract = {{Here we examine the efficiency of different immobilized cell gradients applied to immobilized Saccharomyces cerevisiae fermenting glucose to ethanol. We developed a simulation model to fully study the competing effects of mass transfer hindrance and kinetics. It is based on a diffusion-reaction model and can be used to analyze the different cell concentration profiles inside an immobilized gel bead, in terms of effectiveness factors, productivity, and mass flux. The internal diffusion coefficient, which varies with the local cell concentration, as well as the external mass transfer, is taken into account when describing the efficiency. Although the diffusion hindrance is greater at higher cell concentrations, high cell concentration is still advantageous in the present case because the increase in reaction rate outweighs the diffusion hindrance. Thus, high cell concentrations contribute to increased productivity. The influence of the cell concentration gradient on the efficiency of the beads is negligible, Within the range of cell profiles studied it has been established that the location of the cells within the bead is of lesser importance. However, a steep cell gradient increases the importance of the external mass transfer. (C) 2002 Wiley Periodicals, Inc.}},
author = {{Gutenwik, Jan and Nilsson, Bernt and Axelsson, Anders}},
issn = {{1097-0290}},
keywords = {{cell concentration gradient; variable; simulation; immobilized yeast cells; diffusion; mass transfer}},
language = {{eng}},
number = {{6}},
pages = {{664--673}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Biotechnology and Bioengineering}},
title = {{Mass transfer effects on the reaction rate for heterogeneously distributed immobilized yeast cells}},
url = {{http://dx.doi.org/10.1002/bit.10329}},
doi = {{10.1002/bit.10329}},
volume = {{79}},
year = {{2002}},
}