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Similarity of uterine mucosa changes in patients treated by Raloxifen and Tamoxifen

Willen, R ; Willlen, H and Lindahl, Bengt LU (2002) In Anticancer research 22(2B). p.1121-1125
Abstract
Background: Selective estrogen receptor modulators (SERMS) like Tamoxifen and Raloxifen are used for menopausal symptoms, prevention of cardio-vascular diseases, osteoporosis and mammary carcinoma. Tamoxifen acts as an estrogen inhibitor on the mammary gland, but stimulates postmenopausal uterine mucosa in about 25% of cases while decreasing the risk of osteoporosis. Materials, Methods and Results: In three menopausal women, 56, 79 and 62 years of age, we found uterine mucosal changes similar to what is found in Tamoxifen-treated patients. Using light microscopy and immuno-histopathological techniques, partly cystic mucosa with both atrophic and proliferating glands was found. Strong stromal proliferation was also seen with the typical... (More)
Background: Selective estrogen receptor modulators (SERMS) like Tamoxifen and Raloxifen are used for menopausal symptoms, prevention of cardio-vascular diseases, osteoporosis and mammary carcinoma. Tamoxifen acts as an estrogen inhibitor on the mammary gland, but stimulates postmenopausal uterine mucosa in about 25% of cases while decreasing the risk of osteoporosis. Materials, Methods and Results: In three menopausal women, 56, 79 and 62 years of age, we found uterine mucosal changes similar to what is found in Tamoxifen-treated patients. Using light microscopy and immuno-histopathological techniques, partly cystic mucosa with both atrophic and proliferating glands was found. Strong stromal proliferation was also seen with the typical sharp-edged form of stromal cells and mitoses. A strong ostrogen and progesterone reaction was revealed with immuno-histopathological techniques in both gland and stromal parts. Conclusion: Taking into account the variable amount of different estrogen-receptor types in the uterine mucosa, we can not in the long run expect that no patient will react with estrogen-stimulation features on SERMs like Raloxifen. Further studies and thorough observations are needed to elucidate the true frequency of Raloxifen impact on the uterine mucosa. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
histopathology, uterine mucosa, polyps, Raloxifen
in
Anticancer research
volume
22
issue
2B
pages
1121 - 1125
publisher
International Institute of Cancer Research
external identifiers
  • wos:000177246300014
  • scopus:0036327135
ISSN
1791-7530
language
English
LU publication?
yes
id
f986d2b7-9dcf-47c0-9b63-628c31e03a1b (old id 332165)
date added to LUP
2016-04-01 11:44:38
date last changed
2022-01-26 17:34:25
@article{f986d2b7-9dcf-47c0-9b63-628c31e03a1b,
  abstract     = {{Background: Selective estrogen receptor modulators (SERMS) like Tamoxifen and Raloxifen are used for menopausal symptoms, prevention of cardio-vascular diseases, osteoporosis and mammary carcinoma. Tamoxifen acts as an estrogen inhibitor on the mammary gland, but stimulates postmenopausal uterine mucosa in about 25% of cases while decreasing the risk of osteoporosis. Materials, Methods and Results: In three menopausal women, 56, 79 and 62 years of age, we found uterine mucosal changes similar to what is found in Tamoxifen-treated patients. Using light microscopy and immuno-histopathological techniques, partly cystic mucosa with both atrophic and proliferating glands was found. Strong stromal proliferation was also seen with the typical sharp-edged form of stromal cells and mitoses. A strong ostrogen and progesterone reaction was revealed with immuno-histopathological techniques in both gland and stromal parts. Conclusion: Taking into account the variable amount of different estrogen-receptor types in the uterine mucosa, we can not in the long run expect that no patient will react with estrogen-stimulation features on SERMs like Raloxifen. Further studies and thorough observations are needed to elucidate the true frequency of Raloxifen impact on the uterine mucosa.}},
  author       = {{Willen, R and Willlen, H and Lindahl, Bengt}},
  issn         = {{1791-7530}},
  keywords     = {{histopathology; uterine mucosa; polyps; Raloxifen}},
  language     = {{eng}},
  number       = {{2B}},
  pages        = {{1121--1125}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{Similarity of uterine mucosa changes in patients treated by Raloxifen and Tamoxifen}},
  volume       = {{22}},
  year         = {{2002}},
}