Preliminary study of a genetically engineered spinal cord implant on urinary bladder after experimental spinal cord injury in rats
(2002) In Journal of Rehabilitation Research and Development 39(3). p.347-357- Abstract
- The objective of this study was to determine the effect of neurotrophin-secreting Schwann cell implants on the urinary bladder after spinal cord contusion. One hour after severe spinal cord contusion at the T8 to T11 level, carbon filaments containing nonsecreting Schwann cells, brain-derived neurotrophic factor (BDNF)-secreting Schwann cells, neurotrophin-3 (NT-3)-secreting Schwann cells, or Schwarm cells secreting both BDNF and NT-3 were implanted into the spinal cord. Untreated spinal cord injured (SCI) rats and noncontused rats (C) were also studied. Two months after spinal cord injury, cystometry was performed and the bladders were studied using light microscopy. SCI rats had significantly increased bladder mass, thickness, and smooth... (More)
- The objective of this study was to determine the effect of neurotrophin-secreting Schwann cell implants on the urinary bladder after spinal cord contusion. One hour after severe spinal cord contusion at the T8 to T11 level, carbon filaments containing nonsecreting Schwann cells, brain-derived neurotrophic factor (BDNF)-secreting Schwann cells, neurotrophin-3 (NT-3)-secreting Schwann cells, or Schwarm cells secreting both BDNF and NT-3 were implanted into the spinal cord. Untreated spinal cord injured (SCI) rats and noncontused rats (C) were also studied. Two months after spinal cord injury, cystometry was performed and the bladders were studied using light microscopy. SCI rats had significantly increased bladder mass, thickness, and smooth muscle mass compared to C rats. Bladder capacity of SCI rats and rats with spinal cord implants were both significantly greater than that of C rats. This preliminary study suggests that neurotrophin-secreting Schwann cell implants may lead to improved bladder structure after spinal cord injury. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/332663
- author
- Sakamoto, K ; Uvelius, Bengt LU ; Khan, T and Damaser, MS
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- spinal cord, rat, nerve regeneration, compliance, bladder, capacity, injury, structure
- in
- Journal of Rehabilitation Research and Development
- volume
- 39
- issue
- 3
- pages
- 347 - 357
- publisher
- JRRD
- external identifiers
-
- wos:000176955300006
- scopus:0036587709
- ISSN
- 1938-1352
- language
- English
- LU publication?
- yes
- id
- 8003163c-735a-4fc9-98a6-ba608247b047 (old id 332663)
- alternative location
- http://www.rehab.research.va.gov/jour/02/39/3/sakamoto.htm
- date added to LUP
- 2016-04-01 16:39:15
- date last changed
- 2022-02-27 22:39:28
@article{8003163c-735a-4fc9-98a6-ba608247b047,
abstract = {{The objective of this study was to determine the effect of neurotrophin-secreting Schwann cell implants on the urinary bladder after spinal cord contusion. One hour after severe spinal cord contusion at the T8 to T11 level, carbon filaments containing nonsecreting Schwann cells, brain-derived neurotrophic factor (BDNF)-secreting Schwann cells, neurotrophin-3 (NT-3)-secreting Schwann cells, or Schwarm cells secreting both BDNF and NT-3 were implanted into the spinal cord. Untreated spinal cord injured (SCI) rats and noncontused rats (C) were also studied. Two months after spinal cord injury, cystometry was performed and the bladders were studied using light microscopy. SCI rats had significantly increased bladder mass, thickness, and smooth muscle mass compared to C rats. Bladder capacity of SCI rats and rats with spinal cord implants were both significantly greater than that of C rats. This preliminary study suggests that neurotrophin-secreting Schwann cell implants may lead to improved bladder structure after spinal cord injury.}},
author = {{Sakamoto, K and Uvelius, Bengt and Khan, T and Damaser, MS}},
issn = {{1938-1352}},
keywords = {{spinal cord; rat; nerve regeneration; compliance; bladder; capacity; injury; structure}},
language = {{eng}},
number = {{3}},
pages = {{347--357}},
publisher = {{JRRD}},
series = {{Journal of Rehabilitation Research and Development}},
title = {{Preliminary study of a genetically engineered spinal cord implant on urinary bladder after experimental spinal cord injury in rats}},
url = {{http://www.rehab.research.va.gov/jour/02/39/3/sakamoto.htm}},
volume = {{39}},
year = {{2002}},
}