Diltiazem infusion for renal protection in cardiac surgical patients with preexisting renal dysfunction
(2002) In Journal of Cardiothoracic and Vascular Anesthesia 16(3). p.294-299- Abstract
- Objective: To evaluate if the calcium channel blocker diltiazem protects postoperatively renal function in cardiac surgical patients with preexisting mild-to-moderate renal dysfunction. Design: Prospective, randomized, placebo-controlled, double-blind, clinical study. Setting: Cardiothoracic anesthesia department at a university hospital. Participants: Adult patients undergoing elective cardiac surgery using cardiopulmonary bypass, with a preoperatively elevated serum creatinine level (n = 24). Interventions: Randomized infusions of diltiazem (bolus 0.25 mg/kg followed by a continuous infusion of 1.7 pg/kg/min) (DTZ, n = 12) or placebo (C, n = 12) were started 30 minutes before induction of anesthesia and continued for 24 hours.... (More)
- Objective: To evaluate if the calcium channel blocker diltiazem protects postoperatively renal function in cardiac surgical patients with preexisting mild-to-moderate renal dysfunction. Design: Prospective, randomized, placebo-controlled, double-blind, clinical study. Setting: Cardiothoracic anesthesia department at a university hospital. Participants: Adult patients undergoing elective cardiac surgery using cardiopulmonary bypass, with a preoperatively elevated serum creatinine level (n = 24). Interventions: Randomized infusions of diltiazem (bolus 0.25 mg/kg followed by a continuous infusion of 1.7 pg/kg/min) (DTZ, n = 12) or placebo (C, n = 12) were started 30 minutes before induction of anesthesia and continued for 24 hours. Measurements and Main Results: Median plasma concentrations of diltiazem (DTZ group) were 79 mug/L before cardiopulmonary bypass, 67 mug/L at the end of cardiopulmonary bypass, and 164 mug/L at 24 hours postoperatively. Serum creatinine levels; on postoperative days 1, 3, and 5; and 3 weeks postoperatively were similar between groups. lohexol clearance did not differ between the groups on day 5 but was higher in the DTZ group than in the placebo group 3 weeks after surgery (median, 51 v 40 mL/min/1.73 m(2); p < 0.05). Urinary N-acetyl-β-glucosamidase concentrations were similar between the groups during the study but were increased from baseline on days 2 and 4 and 3 weeks postoperatively. Conclusion: Diltiazem can be safely used in patients who have mild-to-moderate renal dysfunction and undergo cardiac surgery using cardiopulmonary bypass. Within the limits of this study, the data suggest that addition of prophylactic diltiazem may prevent further glomerular damage resulting from cardiopulmonary bypass and may improve glomerular function 3 weeks after cardiac surgery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/334505
- author
- Bergman, ASF ; Odar-Cederlof, I ; Westman, Lars LU ; Bjellerup, P ; Höglund, Peter LU and Ohqvist, G
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- postoperative complications, function, kidney, diltiazem, cardiac surgery, anesthesia, calcium antagonists
- in
- Journal of Cardiothoracic and Vascular Anesthesia
- volume
- 16
- issue
- 3
- pages
- 294 - 299
- publisher
- Elsevier
- external identifiers
-
- wos:000176417200006
- pmid:12073199
- scopus:0036017624
- ISSN
- 1532-8422
- DOI
- 10.1053/jcan.2002.124136
- language
- English
- LU publication?
- yes
- id
- 551ac358-c54c-4c7e-8096-be5b49a42252 (old id 334505)
- date added to LUP
- 2016-04-01 12:35:51
- date last changed
- 2022-01-27 07:17:19
@article{551ac358-c54c-4c7e-8096-be5b49a42252,
abstract = {{Objective: To evaluate if the calcium channel blocker diltiazem protects postoperatively renal function in cardiac surgical patients with preexisting mild-to-moderate renal dysfunction. Design: Prospective, randomized, placebo-controlled, double-blind, clinical study. Setting: Cardiothoracic anesthesia department at a university hospital. Participants: Adult patients undergoing elective cardiac surgery using cardiopulmonary bypass, with a preoperatively elevated serum creatinine level (n = 24). Interventions: Randomized infusions of diltiazem (bolus 0.25 mg/kg followed by a continuous infusion of 1.7 pg/kg/min) (DTZ, n = 12) or placebo (C, n = 12) were started 30 minutes before induction of anesthesia and continued for 24 hours. Measurements and Main Results: Median plasma concentrations of diltiazem (DTZ group) were 79 mug/L before cardiopulmonary bypass, 67 mug/L at the end of cardiopulmonary bypass, and 164 mug/L at 24 hours postoperatively. Serum creatinine levels; on postoperative days 1, 3, and 5; and 3 weeks postoperatively were similar between groups. lohexol clearance did not differ between the groups on day 5 but was higher in the DTZ group than in the placebo group 3 weeks after surgery (median, 51 v 40 mL/min/1.73 m(2); p < 0.05). Urinary N-acetyl-β-glucosamidase concentrations were similar between the groups during the study but were increased from baseline on days 2 and 4 and 3 weeks postoperatively. Conclusion: Diltiazem can be safely used in patients who have mild-to-moderate renal dysfunction and undergo cardiac surgery using cardiopulmonary bypass. Within the limits of this study, the data suggest that addition of prophylactic diltiazem may prevent further glomerular damage resulting from cardiopulmonary bypass and may improve glomerular function 3 weeks after cardiac surgery.}},
author = {{Bergman, ASF and Odar-Cederlof, I and Westman, Lars and Bjellerup, P and Höglund, Peter and Ohqvist, G}},
issn = {{1532-8422}},
keywords = {{postoperative complications; function; kidney; diltiazem; cardiac surgery; anesthesia; calcium antagonists}},
language = {{eng}},
number = {{3}},
pages = {{294--299}},
publisher = {{Elsevier}},
series = {{Journal of Cardiothoracic and Vascular Anesthesia}},
title = {{Diltiazem infusion for renal protection in cardiac surgical patients with preexisting renal dysfunction}},
url = {{http://dx.doi.org/10.1053/jcan.2002.124136}},
doi = {{10.1053/jcan.2002.124136}},
volume = {{16}},
year = {{2002}},
}