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How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?

Carrondo, Manuel J. T. ; Alves, Paula M. ; Carinhas, Nuno ; Glassey, Jarka ; Hesse, Friedemann ; Merten, Otto-Wilhelm ; Micheletti, Martina ; Noll, Thomas ; Oliveira, Rui and Reichl, Udo , et al. (2012) In Biotechnology Journal 7(12). p.1522-1529
Abstract
This report highlights the potential of measurement, monitoring, modeling and control ((MC)-C-3) methodologies in animal and human cell culture technology. In particular, state-of-the-art of (MC)-C-3 technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in (MC)-C-3 are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting (MC)-C-3 research toward the industrial interests. These include issues of importance for biotherapeutics production,... (More)
This report highlights the potential of measurement, monitoring, modeling and control ((MC)-C-3) methodologies in animal and human cell culture technology. In particular, state-of-the-art of (MC)-C-3 technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in (MC)-C-3 are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting (MC)-C-3 research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biopharmaceuticals, Gene therapy, Mammalian cells, Stem cells, Viral, vectors
in
Biotechnology Journal
volume
7
issue
12
pages
1522 - 1529
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000312032500013
  • scopus:84870688374
ISSN
1860-6768
DOI
10.1002/biot.201200226
language
English
LU publication?
yes
id
0ac7e068-72c5-4aa2-964e-ca90069ba8b4 (old id 3367869)
date added to LUP
2016-04-01 09:49:56
date last changed
2023-11-09 05:22:12
@article{0ac7e068-72c5-4aa2-964e-ca90069ba8b4,
  abstract     = {{This report highlights the potential of measurement, monitoring, modeling and control ((MC)-C-3) methodologies in animal and human cell culture technology. In particular, state-of-the-art of (MC)-C-3 technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in (MC)-C-3 are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting (MC)-C-3 research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.}},
  author       = {{Carrondo, Manuel J. T. and Alves, Paula M. and Carinhas, Nuno and Glassey, Jarka and Hesse, Friedemann and Merten, Otto-Wilhelm and Micheletti, Martina and Noll, Thomas and Oliveira, Rui and Reichl, Udo and Staby, Arne and Teixeira, Ana P. and Weichert, Henry and Mandenius, Carl-Fredrik}},
  issn         = {{1860-6768}},
  keywords     = {{Biopharmaceuticals; Gene therapy; Mammalian cells; Stem cells; Viral; vectors}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1522--1529}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Biotechnology Journal}},
  title        = {{How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?}},
  url          = {{http://dx.doi.org/10.1002/biot.201200226}},
  doi          = {{10.1002/biot.201200226}},
  volume       = {{7}},
  year         = {{2012}},
}