Low level of antimicrobial resistance in Escherichia coli among Swedish nursing home residents
Olofsson, Magnus ; Toepfer, Michael ; Ostgren, Carl Johan ; Midlöv, Patrik LU
; Matussek, Andreas
; Lindgren, Per-Eric
and Mölstad, Sigvard
LU
(2013)
In Scandinavian Journal of Infectious Diseases
45(2).
p.117-123
- Abstract
- Background: Screening for bacterial colonization and antimicrobial resistance (AMR) among a defined population could aid in the identification of at-risk populations and provide targets for antibiotic stewardship and infection control programmes. Methods: Two hundred and sixty-eight participants at 11 Swedish nursing homes underwent serial screening for colonization with Escherichia coli between March 2008 and September 2010. Seventy-two of the 268 participants (27%) were male. The median age was 85 y. Samples were collected from urine, the rectal mucosa, the groin, and active skin lesions. Results: Two hundred and nine of 268 participants (78%) were colonized with E. coli at any body site/fluid. The specific colonization rates were 81%... (More)
- Background: Screening for bacterial colonization and antimicrobial resistance (AMR) among a defined population could aid in the identification of at-risk populations and provide targets for antibiotic stewardship and infection control programmes. Methods: Two hundred and sixty-eight participants at 11 Swedish nursing homes underwent serial screening for colonization with Escherichia coli between March 2008 and September 2010. Seventy-two of the 268 participants (27%) were male. The median age was 85 y. Samples were collected from urine, the rectal mucosa, the groin, and active skin lesions. Results: Two hundred and nine of 268 participants (78%) were colonized with E. coli at any body site/fluid. The specific colonization rates were 81% (rectum), 48% (urine), 30% (groin), 59% (unknown), and 13% (skin lesion). An antibiotic-resistant E. coli isolate was identified in 18% of all participants regardless of colonization status; all together, 87 resistant isolates were detected. Only 1 participant carried isolates with resistance to third-generation cephalosporins (cefotaxime and ceftazidime). Conclusions: The presence of resistance was generally low, and the greater part of the resistant cases was connected with 3 common antibiotics: ampicillin, trimethoprim/sulfamethoxazole, and ciprofloxacin. In spite of generally increasing resistance against third-generation cephalosporins in E. coli in Sweden, this study does not implicate residence at a Swedish nursing home as a risk factor for the acquisition of expressed cephalosporin resistance. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3470513
- author
- Olofsson, Magnus
; Toepfer, Michael
; Ostgren, Carl Johan
; Midlöv, Patrik
LU
; Matussek, Andreas
; Lindgren, Per-Eric
and Mölstad, Sigvard
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Mass screening, colonization, nursing homes, drug resistance, bacterial, Escherichia coli
- in
- Scandinavian Journal of Infectious Diseases
- volume
- 45
- issue
- 2
- pages
- 117 - 123
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000313677200006
- scopus:84872332120
- pmid:22992114
- ISSN
- 1651-1980
- DOI
- 10.3109/00365548.2012.717232
- language
- English
- LU publication?
- yes
- id
- c1788180-3d6c-4b0d-a8a0-937811617a3d (old id 3470513)
- date added to LUP
- 2016-04-01 14:15:12
- date last changed
- 2022-04-01 02:30:22
@article{c1788180-3d6c-4b0d-a8a0-937811617a3d,
abstract = {{Background: Screening for bacterial colonization and antimicrobial resistance (AMR) among a defined population could aid in the identification of at-risk populations and provide targets for antibiotic stewardship and infection control programmes. Methods: Two hundred and sixty-eight participants at 11 Swedish nursing homes underwent serial screening for colonization with Escherichia coli between March 2008 and September 2010. Seventy-two of the 268 participants (27%) were male. The median age was 85 y. Samples were collected from urine, the rectal mucosa, the groin, and active skin lesions. Results: Two hundred and nine of 268 participants (78%) were colonized with E. coli at any body site/fluid. The specific colonization rates were 81% (rectum), 48% (urine), 30% (groin), 59% (unknown), and 13% (skin lesion). An antibiotic-resistant E. coli isolate was identified in 18% of all participants regardless of colonization status; all together, 87 resistant isolates were detected. Only 1 participant carried isolates with resistance to third-generation cephalosporins (cefotaxime and ceftazidime). Conclusions: The presence of resistance was generally low, and the greater part of the resistant cases was connected with 3 common antibiotics: ampicillin, trimethoprim/sulfamethoxazole, and ciprofloxacin. In spite of generally increasing resistance against third-generation cephalosporins in E. coli in Sweden, this study does not implicate residence at a Swedish nursing home as a risk factor for the acquisition of expressed cephalosporin resistance.}},
author = {{Olofsson, Magnus and Toepfer, Michael and Ostgren, Carl Johan and Midlöv, Patrik and Matussek, Andreas and Lindgren, Per-Eric and Mölstad, Sigvard}},
issn = {{1651-1980}},
keywords = {{Mass screening; colonization; nursing homes; drug resistance; bacterial; Escherichia coli}},
language = {{eng}},
number = {{2}},
pages = {{117--123}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Infectious Diseases}},
title = {{Low level of antimicrobial resistance in Escherichia coli among Swedish nursing home residents}},
url = {{http://dx.doi.org/10.3109/00365548.2012.717232}},
doi = {{10.3109/00365548.2012.717232}},
volume = {{45}},
year = {{2013}},
}