Three per cent dextran-60 as a plasma substitute in blood component therapy. I. An alternative in surgical blood loss replacement.
(1985) In Acta Anaesthesiologica Scandinavica 29(8). p.767-774- Abstract
- Microaggregate-poor erythrocyte concentrate with 3% dextran-60 as a plasma substitute was compared with microaggregate-poor whole blood for replacement of intra-operative and immediately postoperative blood loss. Sixty patients undergoing total hip arthroplasty randomly received either of these two forms of therapy. In accordance with the clinical routine of our orthopedic department, an infusion of 500 ml of 6% dextran-70 (Macrodex) was given as thrombo-prophylaxis in both groups. Use of 3% dextran-60 as a plasma substitute in blood component therapy for surgical hemorrhage of up to 50% of the calculated blood volume caused no increase in bleeding tendency or frequency of postoperative hematoma compared with whole blood replacement.... (More)
- Microaggregate-poor erythrocyte concentrate with 3% dextran-60 as a plasma substitute was compared with microaggregate-poor whole blood for replacement of intra-operative and immediately postoperative blood loss. Sixty patients undergoing total hip arthroplasty randomly received either of these two forms of therapy. In accordance with the clinical routine of our orthopedic department, an infusion of 500 ml of 6% dextran-70 (Macrodex) was given as thrombo-prophylaxis in both groups. Use of 3% dextran-60 as a plasma substitute in blood component therapy for surgical hemorrhage of up to 50% of the calculated blood volume caused no increase in bleeding tendency or frequency of postoperative hematoma compared with whole blood replacement. Plasma protein levels were low immediately postoperatively in patients given the dextran, but from the 4th postoperative day onward there was no difference between the groups. Applied in clinical practice, this would be efficient in saving plasma for other urgent purposes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3634435
- author
- Schött, Ulf LU ; Sjöstrand, U ; Thorén, T and Berséus, O
- publishing date
- 1985
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Plasma Substitutes: therapeutic use, Hemorrhage: therapy, Blood Proteins: analysis, Dextrans: therapeutic use, Surgical Procedures, Operative: adverse effects
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 29
- issue
- 8
- pages
- 767 - 774
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:2417434
- scopus:0022399904
- ISSN
- 0001-5172
- project
- Koagulation vid kirurgi och kritisk sjukdom
- language
- English
- LU publication?
- no
- id
- 8af2a0f2-b8e2-487d-9bf0-1271f93983c2 (old id 3634435)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/2417434?dopt=Abstract
- date added to LUP
- 2016-04-04 08:23:36
- date last changed
- 2021-09-19 03:17:26
@article{8af2a0f2-b8e2-487d-9bf0-1271f93983c2,
abstract = {{Microaggregate-poor erythrocyte concentrate with 3% dextran-60 as a plasma substitute was compared with microaggregate-poor whole blood for replacement of intra-operative and immediately postoperative blood loss. Sixty patients undergoing total hip arthroplasty randomly received either of these two forms of therapy. In accordance with the clinical routine of our orthopedic department, an infusion of 500 ml of 6% dextran-70 (Macrodex) was given as thrombo-prophylaxis in both groups. Use of 3% dextran-60 as a plasma substitute in blood component therapy for surgical hemorrhage of up to 50% of the calculated blood volume caused no increase in bleeding tendency or frequency of postoperative hematoma compared with whole blood replacement. Plasma protein levels were low immediately postoperatively in patients given the dextran, but from the 4th postoperative day onward there was no difference between the groups. Applied in clinical practice, this would be efficient in saving plasma for other urgent purposes.}},
author = {{Schött, Ulf and Sjöstrand, U and Thorén, T and Berséus, O}},
issn = {{0001-5172}},
keywords = {{Plasma Substitutes: therapeutic use; Hemorrhage: therapy; Blood Proteins: analysis; Dextrans: therapeutic use; Surgical Procedures; Operative: adverse effects}},
language = {{eng}},
number = {{8}},
pages = {{767--774}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Anaesthesiologica Scandinavica}},
title = {{Three per cent dextran-60 as a plasma substitute in blood component therapy. I. An alternative in surgical blood loss replacement.}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/2417434?dopt=Abstract}},
volume = {{29}},
year = {{1985}},
}