Molecular characterization of the immune system: emergence of proteins, processes, and domains.
Ortutay, Csaba ; Siermala, Markku and Vihinen, Mauno LU
(2007)
In Immunogenetics
59(5).
p.333-348
- Abstract
- Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of... (More)
- Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of immune processes based on gene orthologs to gain an overview of the evolutionary past and molecular present of the human immune system. A list of genes and proteins were compiled. A comprehensive characterization of the member genes and proteins, including the corresponding pseudogenes is presented. Immunome genes were found to have three types of emergence in independent studies of their ontologies, domains, and functions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3635326
- author
- Ortutay, Csaba
; Siermala, Markku
and Vihinen, Mauno
LU
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Immunity: genetics, Human: genetics, Chromosomes, Immune System: immunology, Proteins: classification, Proteins: genetics
- in
- Immunogenetics
- volume
- 59
- issue
- 5
- pages
- 333 - 348
- publisher
- Springer
- external identifiers
-
- pmid:17294181
- scopus:34047199156
- ISSN
- 1432-1211
- DOI
- 10.1007/s00251-007-0191-0
- language
- English
- LU publication?
- no
- id
- 179ff39f-e0d1-44f1-a224-0beaed42bf82 (old id 3635326)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/17294181?dopt=Abstract
- date added to LUP
- 2016-04-04 09:26:22
- date last changed
- 2022-01-29 17:54:37
@article{179ff39f-e0d1-44f1-a224-0beaed42bf82,
abstract = {{Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of immune processes based on gene orthologs to gain an overview of the evolutionary past and molecular present of the human immune system. A list of genes and proteins were compiled. A comprehensive characterization of the member genes and proteins, including the corresponding pseudogenes is presented. Immunome genes were found to have three types of emergence in independent studies of their ontologies, domains, and functions.}},
author = {{Ortutay, Csaba and Siermala, Markku and Vihinen, Mauno}},
issn = {{1432-1211}},
keywords = {{Immunity: genetics; Human: genetics; Chromosomes; Immune System: immunology; Proteins: classification; Proteins: genetics}},
language = {{eng}},
number = {{5}},
pages = {{333--348}},
publisher = {{Springer}},
series = {{Immunogenetics}},
title = {{Molecular characterization of the immune system: emergence of proteins, processes, and domains.}},
url = {{http://dx.doi.org/10.1007/s00251-007-0191-0}},
doi = {{10.1007/s00251-007-0191-0}},
volume = {{59}},
year = {{2007}},
}