Classical conditioning of motor responses: What is the learning mechanism?
Hesslow, Germund LU ; Jirenhed, Dan-Anders LU ; Rasmussen, Anders LU
and Johansson, Fredrik
LU
(2013)
In Neural Networks
47(Mar,28).
p.81-87
- Abstract
- According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major challenges to the LTD hypothesis of conditioning. (i) LTD cannot account for the pause in Purkinje cell firing that is believed to drive the conditioned blink. (ii) The temporal conditions conducive to LTD do not match those for eyeblink conditioning. (iii) LTD cannot readily account for the adaptive timing of the conditioned response. (iv) The data... (More)
- According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major challenges to the LTD hypothesis of conditioning. (i) LTD cannot account for the pause in Purkinje cell firing that is believed to drive the conditioned blink. (ii) The temporal conditions conducive to LTD do not match those for eyeblink conditioning. (iii) LTD cannot readily account for the adaptive timing of the conditioned response. (iv) The data suggest that parallel fibre to Purkinje cell synapses are not depressed after learning a Purkinje cell CR. Models based on metabotropic glutamate receptors are also discussed and found to be incompatible with the recording data. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3733593
- author
- Hesslow, Germund
LU
; Jirenhed, Dan-Anders
LU
; Rasmussen, Anders
LU
and Johansson, Fredrik
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neural Networks
- volume
- 47
- issue
- Mar,28
- pages
- 81 - 87
- publisher
- Elsevier
- external identifiers
-
- wos:000325446800011
- pmid:23597758
- scopus:84884141397
- pmid:23597758
- ISSN
- 1879-2782
- DOI
- 10.1016/j.neunet.2013.03.013
- project
- Thinking in Time: Cognition, Communication and Learning
- language
- English
- LU publication?
- yes
- id
- deda081e-2253-4680-82b1-34dff6ec825c (old id 3733593)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23597758?dopt=Abstract
- date added to LUP
- 2016-04-01 10:37:43
- date last changed
- 2022-05-16 12:08:51
@article{deda081e-2253-4680-82b1-34dff6ec825c,
abstract = {{According to a widely held assumption, the main mechanism underlying motor learning in the cerebellum, such as eyeblink conditioning, is long-term depression (LTD) of parallel fibre to Purkinje cell synapses. Here we review some recent physiological evidence from Purkinje cell recordings during conditioning with implications for models of conditioning. We argue that these data pose four major challenges to the LTD hypothesis of conditioning. (i) LTD cannot account for the pause in Purkinje cell firing that is believed to drive the conditioned blink. (ii) The temporal conditions conducive to LTD do not match those for eyeblink conditioning. (iii) LTD cannot readily account for the adaptive timing of the conditioned response. (iv) The data suggest that parallel fibre to Purkinje cell synapses are not depressed after learning a Purkinje cell CR. Models based on metabotropic glutamate receptors are also discussed and found to be incompatible with the recording data.}},
author = {{Hesslow, Germund and Jirenhed, Dan-Anders and Rasmussen, Anders and Johansson, Fredrik}},
issn = {{1879-2782}},
language = {{eng}},
number = {{Mar,28}},
pages = {{81--87}},
publisher = {{Elsevier}},
series = {{Neural Networks}},
title = {{Classical conditioning of motor responses: What is the learning mechanism?}},
url = {{http://dx.doi.org/10.1016/j.neunet.2013.03.013}},
doi = {{10.1016/j.neunet.2013.03.013}},
volume = {{47}},
year = {{2013}},
}